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@ARTICLE{Rotta:157814,
      author       = {Rotta, Johanna and Perosa, Valentina and Yakupov, Renat and
                      Kuijf, Hugo J and Schreiber, Frank and Dobisch, Laura and
                      Oltmer, Jan and Assmann, Anne and Speck, Oliver and Heinze,
                      Hans-Jochen and Acosta-Cabronero, Julio and Düzel, Emrah
                      and Schreiber, Stefanie},
      title        = {{D}etection of {C}erebral {M}icrobleeds {W}ith {V}enous
                      {C}onnection at 7-{T}esla {MRI}.},
      journal      = {Neurology},
      volume       = {96},
      number       = {16},
      issn         = {1526-632X},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {DZNE-2021-01271},
      pages        = {e2048 - e2057},
      year         = {2021},
      abstract     = {Cerebral microbleeds (MBs) are a common finding in patients
                      with cerebral small vessel disease (CSVD) and Alzheimer
                      disease as well as in healthy elderly people, but their
                      pathophysiology remains unclear. To investigate a possible
                      role of veins in the development of MBs, we performed an
                      exploratory study, assessing in vivo presence of MBs with a
                      direct connection to a vein.7-Tesla (7T) MRI was conducted
                      and MBs were counted on quantitative susceptibility mapping
                      (QSM). A submillimeter resolution QSM-based venogram allowed
                      identification of MBs with a direct spatial connection to a
                      vein.A total of 51 people (mean age [SD] 70.5 [8.6] years,
                      $37\%$ female) participated in the study: 20 had CSVD
                      (cerebral amyloid angiopathy [CAA] with strictly lobar MBs
                      [n = 8], hypertensive arteriopathy [HA] with strictly deep
                      MBs [n = 5], or mixed lobar and deep MBs [n = 7], 72.4 [6.1]
                      years, $30\%$ female) and 31 were healthy controls (69.4
                      [9.9] years, $42\%$ female). In our cohort, we counted a
                      total of 96 MBs with a venous connection, representing
                      $14\%$ of all detected MBs on 7T QSM. Most venous MBs
                      $(86\%,$ n = 83) were observed in lobar locations and all of
                      these were cortical. Patients with CAA showed the highest
                      ratio of venous to total MBs $(19\%)$ (HA = $9\%,$ mixed =
                      $18\%,$ controls = $5\%).Our$ findings establish a link
                      between cerebral MBs and the venous vasculature, pointing
                      towards a possible contribution of veins to CSVD in general
                      and to CAA in particular. Pathologic studies are needed to
                      confirm our observations.},
      keywords     = {Aged / Cerebral Hemorrhage: diagnostic imaging / Cerebral
                      Hemorrhage: etiology / Cerebral Hemorrhage: pathology /
                      Cerebral Small Vessel Diseases: complications / Cerebral
                      Small Vessel Diseases: pathology / Female / Humans / Image
                      Interpretation, Computer-Assisted / Magnetic Resonance
                      Imaging / Male / Middle Aged / Neuroimaging: methods /
                      Veins: diagnostic imaging / Veins: pathology},
      cin          = {AG Düzel / AG Schreiber / AG Speck / AG Wolbers / AG
                      Nestor / U Clinical Researchers - Magdeburg},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006 / I:(DE-2719)1310010 /
                      I:(DE-2719)1340009 / I:(DE-2719)1310002 / I:(DE-2719)1310001
                      / I:(DE-2719)7000000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33653897},
      doi          = {10.1212/WNL.0000000000011790},
      url          = {https://pub.dzne.de/record/157814},
}