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000157827 1001_ $$0P:(DE-2719)2501739$$aDonix, Markus$$b0$$eFirst author$$udzne
000157827 245__ $$aRelation of retinal and hippocampal thickness in patients with amnestic mild cognitive impairment and healthy controls.
000157827 260__ $$aMalden, Mass.$$bWiley$$c2021
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000157827 520__ $$aInvestigating retinal thickness may complement existing biological markers for dementia and other neurodegenerative diseases. Although retinal thinning is predictive for cognitive decline, it remains to be investigated if and how this feature aligns with neurodegeneration elsewhere in the brain, specifically in early disease stages.Using optical coherence tomography and magnetic resonance imaging, we examined retinal thickness as well as hippocampal structure in patients with amnestic mild cognitive impairment and healthy controls.The groups did not differ in hippocampal and retinal thickness measures. However, we detected a correlation of peripapillary retinal nerve fiber layer thickness and hippocampal thickness in healthy people but not in cognitively impaired patients. The ratio of hippocampus to retina thickness was significantly smaller in patients with mild cognitive impairment and correlated positively with cognitive performance.Different temporal trajectories of neurodegeneration may disrupt transregional brain structure associations in patients with amnestic mild cognitive impairment.
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000157827 650_7 $$2Other$$ahippocampus
000157827 650_7 $$2Other$$amagnetic resonance imaging
000157827 650_7 $$2Other$$amild cognitive impairment
000157827 650_7 $$2Other$$aoptical coherence tomography
000157827 650_7 $$2Other$$aretina
000157827 650_2 $$2MeSH$$aAlzheimer Disease
000157827 650_2 $$2MeSH$$aBrain
000157827 650_2 $$2MeSH$$aCognitive Dysfunction: diagnostic imaging
000157827 650_2 $$2MeSH$$aHippocampus: diagnostic imaging
000157827 650_2 $$2MeSH$$aHumans
000157827 650_2 $$2MeSH$$aRetina: diagnostic imaging
000157827 650_2 $$2MeSH$$aTomography, Optical Coherence
000157827 7001_ $$aWittig, Dierk$$b1
000157827 7001_ $$0P:(DE-2719)2814194$$aHermann, Wiebke$$b2$$udzne
000157827 7001_ $$0P:(DE-2719)9000458$$aHaussmann, Robert$$b3$$udzne
000157827 7001_ $$aDittmer, Maren$$b4
000157827 7001_ $$aBienert, Franziska$$b5
000157827 7001_ $$aButhut, Maria$$b6
000157827 7001_ $$aJacobi, Liane$$b7
000157827 7001_ $$0P:(DE-2719)2812330$$aWerner, Annett$$b8$$udzne
000157827 7001_ $$aLinn, Jennifer$$b9
000157827 7001_ $$aZiemssen, Tjalf$$b10
000157827 7001_ $$0P:(DE-2719)2812107$$aBrandt, Daniel Moritz$$b11$$eLast author$$udzne
000157827 773__ $$0PERI:(DE-600)2623587-0$$a10.1002/brb3.2035$$gVol. 11, no. 5$$n5$$pe02035$$tBrain and behavior$$v11$$x2162-3279$$y2021
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