TY  - JOUR
AU  - Donix, Markus
AU  - Wittig, Dierk
AU  - Hermann, Wiebke
AU  - Haussmann, Robert
AU  - Dittmer, Maren
AU  - Bienert, Franziska
AU  - Buthut, Maria
AU  - Jacobi, Liane
AU  - Werner, Annett
AU  - Linn, Jennifer
AU  - Ziemssen, Tjalf
AU  - Brandt, Daniel Moritz
TI  - Relation of retinal and hippocampal thickness in patients with amnestic mild cognitive impairment and healthy controls.
JO  - Brain and behavior
VL  - 11
IS  - 5
SN  - 2162-3279
CY  - Malden, Mass.
PB  - Wiley
M1  - DZNE-2021-01284
SP  - e02035
PY  - 2021
N1  - (CC BY)
AB  - Investigating retinal thickness may complement existing biological markers for dementia and other neurodegenerative diseases. Although retinal thinning is predictive for cognitive decline, it remains to be investigated if and how this feature aligns with neurodegeneration elsewhere in the brain, specifically in early disease stages.Using optical coherence tomography and magnetic resonance imaging, we examined retinal thickness as well as hippocampal structure in patients with amnestic mild cognitive impairment and healthy controls.The groups did not differ in hippocampal and retinal thickness measures. However, we detected a correlation of peripapillary retinal nerve fiber layer thickness and hippocampal thickness in healthy people but not in cognitively impaired patients. The ratio of hippocampus to retina thickness was significantly smaller in patients with mild cognitive impairment and correlated positively with cognitive performance.Different temporal trajectories of neurodegeneration may disrupt transregional brain structure associations in patients with amnestic mild cognitive impairment.
KW  - Alzheimer Disease
KW  - Brain
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Hippocampus: diagnostic imaging
KW  - Humans
KW  - Retina: diagnostic imaging
KW  - Tomography, Optical Coherence
KW  - hippocampus (Other)
KW  - magnetic resonance imaging (Other)
KW  - mild cognitive impairment (Other)
KW  - optical coherence tomography (Other)
KW  - retina (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33448670
C2  - pmc:PMC8119792
DO  - DOI:10.1002/brb3.2035
UR  - https://pub.dzne.de/record/157827
ER  -