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@ARTICLE{Donix:157827,
      author       = {Donix, Markus and Wittig, Dierk and Hermann, Wiebke and
                      Haussmann, Robert and Dittmer, Maren and Bienert, Franziska
                      and Buthut, Maria and Jacobi, Liane and Werner, Annett and
                      Linn, Jennifer and Ziemssen, Tjalf and Brandt, Daniel
                      Moritz},
      title        = {{R}elation of retinal and hippocampal thickness in patients
                      with amnestic mild cognitive impairment and healthy
                      controls.},
      journal      = {Brain and behavior},
      volume       = {11},
      number       = {5},
      issn         = {2162-3279},
      address      = {Malden, Mass.},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-01284},
      pages        = {e02035},
      year         = {2021},
      note         = {(CC BY)},
      abstract     = {Investigating retinal thickness may complement existing
                      biological markers for dementia and other neurodegenerative
                      diseases. Although retinal thinning is predictive for
                      cognitive decline, it remains to be investigated if and how
                      this feature aligns with neurodegeneration elsewhere in the
                      brain, specifically in early disease stages.Using optical
                      coherence tomography and magnetic resonance imaging, we
                      examined retinal thickness as well as hippocampal structure
                      in patients with amnestic mild cognitive impairment and
                      healthy controls.The groups did not differ in hippocampal
                      and retinal thickness measures. However, we detected a
                      correlation of peripapillary retinal nerve fiber layer
                      thickness and hippocampal thickness in healthy people but
                      not in cognitively impaired patients. The ratio of
                      hippocampus to retina thickness was significantly smaller in
                      patients with mild cognitive impairment and correlated
                      positively with cognitive performance.Different temporal
                      trajectories of neurodegeneration may disrupt transregional
                      brain structure associations in patients with amnestic mild
                      cognitive impairment.},
      keywords     = {Alzheimer Disease / Brain / Cognitive Dysfunction:
                      diagnostic imaging / Hippocampus: diagnostic imaging /
                      Humans / Retina: diagnostic imaging / Tomography, Optical
                      Coherence / hippocampus (Other) / magnetic resonance imaging
                      (Other) / mild cognitive impairment (Other) / optical
                      coherence tomography (Other) / retina (Other)},
      cin          = {Clinical Study Team Dresden ; AG Falkenburger / AG Teipel /
                      AG Donix / AG Karl},
      ddc          = {610},
      cid          = {I:(DE-2719)1710012 / I:(DE-2719)1510100 /
                      I:(DE-2719)1710008 / I:(DE-2719)1710004},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33448670},
      pmc          = {pmc:PMC8119792},
      doi          = {10.1002/brb3.2035},
      url          = {https://pub.dzne.de/record/157827},
}