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001     157827
005     20230915092358.0
024 7 _ |a 10.1002/brb3.2035
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037 _ _ |a DZNE-2021-01284
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082 _ _ |a 610
100 1 _ |a Donix, Markus
|0 P:(DE-2719)2501739
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245 _ _ |a Relation of retinal and hippocampal thickness in patients with amnestic mild cognitive impairment and healthy controls.
260 _ _ |a Malden, Mass.
|c 2021
|b Wiley
336 7 _ |a article
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520 _ _ |a Investigating retinal thickness may complement existing biological markers for dementia and other neurodegenerative diseases. Although retinal thinning is predictive for cognitive decline, it remains to be investigated if and how this feature aligns with neurodegeneration elsewhere in the brain, specifically in early disease stages.Using optical coherence tomography and magnetic resonance imaging, we examined retinal thickness as well as hippocampal structure in patients with amnestic mild cognitive impairment and healthy controls.The groups did not differ in hippocampal and retinal thickness measures. However, we detected a correlation of peripapillary retinal nerve fiber layer thickness and hippocampal thickness in healthy people but not in cognitively impaired patients. The ratio of hippocampus to retina thickness was significantly smaller in patients with mild cognitive impairment and correlated positively with cognitive performance.Different temporal trajectories of neurodegeneration may disrupt transregional brain structure associations in patients with amnestic mild cognitive impairment.
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650 _ 7 |a hippocampus
|2 Other
650 _ 7 |a magnetic resonance imaging
|2 Other
650 _ 7 |a mild cognitive impairment
|2 Other
650 _ 7 |a optical coherence tomography
|2 Other
650 _ 7 |a retina
|2 Other
650 _ 2 |a Alzheimer Disease
|2 MeSH
650 _ 2 |a Brain
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: diagnostic imaging
|2 MeSH
650 _ 2 |a Hippocampus: diagnostic imaging
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Retina: diagnostic imaging
|2 MeSH
650 _ 2 |a Tomography, Optical Coherence
|2 MeSH
700 1 _ |a Wittig, Dierk
|b 1
700 1 _ |a Hermann, Wiebke
|0 P:(DE-2719)2814194
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700 1 _ |a Haussmann, Robert
|0 P:(DE-2719)9000458
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700 1 _ |a Dittmer, Maren
|b 4
700 1 _ |a Bienert, Franziska
|b 5
700 1 _ |a Buthut, Maria
|b 6
700 1 _ |a Jacobi, Liane
|b 7
700 1 _ |a Werner, Annett
|0 P:(DE-2719)2812330
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700 1 _ |a Linn, Jennifer
|b 9
700 1 _ |a Ziemssen, Tjalf
|b 10
700 1 _ |a Brandt, Daniel Moritz
|0 P:(DE-2719)2812107
|b 11
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773 _ _ |a 10.1002/brb3.2035
|g Vol. 11, no. 5
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|n 5
|p e02035
|t Brain and behavior
|v 11
|y 2021
|x 2162-3279
856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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