TY  - JOUR
AU  - Lu, Ran
AU  - Aziz, N Ahmad
AU  - Reuter, Martin
AU  - Stöcker, Tony
AU  - Breteler, Monique M B
TI  - Evaluation of the Neuroanatomical Basis of Olfactory Dysfunction in the General Population
JO  - JAMA otolaryngology - head & neck surgery
VL  - 147
IS  - 10
SN  - 2168-6181
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DZNE-2021-01293
SP  - 855 - 863
PY  - 2021
AB  - Olfactory dysfunction is a prodromal manifestation of many neurodegenerative disorders, including Alzheimer and Parkinson disease. However, its neuroanatomical basis is largely unknown.To assess the association between olfactory brain structures and olfactory function in adults 30 years or older and to examine the extent to which olfactory bulb volume (OBV) mediates the association between central olfactory structures and olfactory function.This cross-sectional study analyzed baseline data from the first 639 participants with brain magnetic resonance imaging (MRI) in the Rhineland Study, an ongoing population-based cohort study in Bonn, Germany. Participants were enrolled between March 7, 2016, and October 31, 2017, and underwent brain MRI and olfactory assessment. Data were analyzed from March 1, 2018, to June 30, 2021.Volumetric measures were derived from 3-T MRI T1-weighted brain scans, and OBV was manually segmented on T2-weighted images. The mean volumetric brain measures from the right and left sides were calculated, adjusted by head size, and normalized to all participants.Performance on the 12-item smell identification test (SIT-12) was used as a proxy for olfactory function.A total of 541 participants with complete data on MRI-derived measures and SIT-12 scores were included. This population had a mean (SD) age of 53.6 (13.1) years and comprised 306 women (56.6
KW  - Adult
KW  - Aged
KW  - Amygdala: diagnostic imaging
KW  - Cerebral Cortex: diagnostic imaging
KW  - Cross-Sectional Studies
KW  - Female
KW  - Germany
KW  - Hippocampus: diagnostic imaging
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Olfaction Disorders: diagnostic imaging
KW  - Olfaction Disorders: physiopathology
KW  - Olfactory Bulb: diagnostic imaging
KW  - Organ Size
KW  - Prefrontal Cortex: diagnostic imaging
LB  - PUB:(DE-HGF)16
C6  - pmid:34436517
C2  - pmc:PMC8391780
DO  - DOI:10.1001/jamaoto.2021.2026
UR  - https://pub.dzne.de/record/162239
ER  -