TY  - EJOUR
AU  - Boettcher, Adriana
AU  - Zarucha, Alexis
AU  - Koebe, Theresa
AU  - Gaubert, Malo
AU  - Höppner, Angela
AU  - Fabel, Klaus
AU  - Altenstein, Slawek
AU  - Bartels, Claudia
AU  - Bürger, Katharina
AU  - Dechent, Peter
AU  - Dobisch, Laura
AU  - Ewers, Michael
AU  - Fliessbach, Klaus
AU  - Freiesleben, Silka Dawn
AU  - Frommann, Ingo
AU  - Haynes, John Dylan
AU  - Janowitz, Daniel
AU  - Kilimann, Ingo
AU  - Kleineidam, Luca
AU  - Laske, Christoph
AU  - Maier, Franziska
AU  - Metzger, Coraline
AU  - Munk, Mathias H.
AU  - Perneczky, Robert
AU  - Peters, Oliver
AU  - Priller, Josef
AU  - Rauchmann, Boris-Stephan
AU  - Roy, Nina
AU  - Scheffler, Klaus
AU  - Schneider, Anja
AU  - Spottke, Annika
AU  - Teipel, Stefan J.
AU  - Wiltfang, Jens
AU  - Wolfsgruber, Steffen
AU  - Yakupov, Renat
AU  - Duzel, Emrah
AU  - Jessen, Frank
AU  - Röske, Sandra
AU  - Wagner, Michael
AU  - Kempermann, Gerd
AU  - Wirth, Miranka
TI  - Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults
M1  - DZNE-2021-01299
PY  - 2021
AB  - Regular musical activity as a highly-stimulating lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease (AD). This study investigated associations between lifelong regular musical instrument playing, late-life cognitive abilities and brain morphology in older adults. We show that musical activity over the life course is associated with better global cognition, working memory, executive functions, language, and visuospatial abilities accounting for reserve proxies. Playing music is not significantly associated with gray matter volume in regions most affected by aging and AD. Selectively in the musically active participants, multi-domain cognitive abilities were enhanced with preserved gray matter volume in frontal and temporal regions. Our correlational findings suggest that playing a musical instrument may improve the recruitment of existing brain resources to facilitate late-life cognitive capacities. We propose that engaging in regular musical activity could serve as a low-threshold multimodal enrichment strategy that may promote cognitive resilience in advanced age.
LB  - PUB:(DE-HGF)25
DO  - DOI:10.1101/2021.09.15.460202
UR  - https://pub.dzne.de/record/162594
ER  -