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@ARTICLE{Boettcher:162594,
      author       = {Boettcher, Adriana and Zarucha, Alexis and Koebe, Theresa
                      and Gaubert, Malo and Höppner, Angela and Fabel, Klaus and
                      Altenstein, Slawek and Bartels, Claudia and Bürger,
                      Katharina and Dechent, Peter and Dobisch, Laura and Ewers,
                      Michael and Fliessbach, Klaus and Freiesleben, Silka Dawn
                      and Frommann, Ingo and Haynes, John Dylan and Janowitz,
                      Daniel and Kilimann, Ingo and Kleineidam, Luca and Laske,
                      Christoph and Maier, Franziska and Metzger, Coraline and
                      Munk, Mathias H. and Perneczky, Robert and Peters, Oliver
                      and Priller, Josef and Rauchmann, Boris-Stephan and Roy,
                      Nina and Scheffler, Klaus and Schneider, Anja and Spottke,
                      Annika and Teipel, Stefan J. and Wiltfang, Jens and
                      Wolfsgruber, Steffen and Yakupov, Renat and Duzel, Emrah and
                      Jessen, Frank and Röske, Sandra and Wagner, Michael and
                      Kempermann, Gerd and Wirth, Miranka},
      title        = {{L}ifelong musical activity is associated with multi-domain
                      cognitive and brain benefits in older adults},
      reportid     = {DZNE-2021-01299},
      year         = {2021},
      abstract     = {Regular musical activity as a highly-stimulating lifestyle
                      activity is proposed to be protective against age-related
                      cognitive decline and Alzheimer’s disease (AD). This study
                      investigated associations between lifelong regular musical
                      instrument playing, late-life cognitive abilities and brain
                      morphology in older adults. We show that musical activity
                      over the life course is associated with better global
                      cognition, working memory, executive functions, language,
                      and visuospatial abilities accounting for reserve proxies.
                      Playing music is not significantly associated with gray
                      matter volume in regions most affected by aging and AD.
                      Selectively in the musically active participants,
                      multi-domain cognitive abilities were enhanced with
                      preserved gray matter volume in frontal and temporal
                      regions. Our correlational findings suggest that playing a
                      musical instrument may improve the recruitment of existing
                      brain resources to facilitate late-life cognitive
                      capacities. We propose that engaging in regular musical
                      activity could serve as a low-threshold multimodal
                      enrichment strategy that may promote cognitive resilience in
                      advanced age.},
      cin          = {AG Wirth / AG Donix / AG White / AG Endres / Clinical
                      Research (Munich) / AG Speck / AG Simons / Patient Studies
                      Bonn / AG Wagner / AG Teipel / Core ICRU / AG Gasser / AG
                      Priller / Clinical Research Platform (CRP) / AG Schneider /
                      AG Klockgether / AG Wiltfang / AG Düzel / AG Jessen / AG
                      Kempermann},
      cid          = {I:(DE-2719)1710011 / I:(DE-2719)1710008 /
                      I:(DE-2719)1740002 / I:(DE-2719)1811005 / I:(DE-2719)1111015
                      / I:(DE-2719)1340009 / I:(DE-2719)1110008 /
                      I:(DE-2719)1011101 / I:(DE-2719)1011201 / I:(DE-2719)1510100
                      / I:(DE-2719)1240005 / I:(DE-2719)1210000 /
                      I:(DE-2719)5000007 / I:(DE-2719)1011401 / I:(DE-2719)1011305
                      / I:(DE-2719)1011001 / I:(DE-2719)1410006 /
                      I:(DE-2719)5000006 / I:(DE-2719)1011102 /
                      I:(DE-2719)1710001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 352 -
                      Disease Mechanisms (POF4-352) / 351 - Brain Function
                      (POF4-351)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-352 /
                      G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2021.09.15.460202},
      url          = {https://pub.dzne.de/record/162594},
}