guest ::
| Home > Publications Database > Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults > print |
| Home > Publications Database > Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults > print |
| 001 | 162594 | ||
| 005 | 20240826165944.0 | ||
| 024 | 7 | _ | |a 10.1101/2021.09.15.460202 |2 doi |
| 024 | 7 | _ | |a altmetric:113633299 |2 altmetric |
| 037 | _ | _ | |a DZNE-2021-01299 |
| 041 | _ | _ | |a English |
| 100 | 1 | _ | |a Boettcher, Adriana |0 P:(DE-2719)9000495 |b 0 |e First author |
| 245 | _ | _ | |a Lifelong musical activity is associated with multi-domain cognitive and brain benefits in older adults |
| 260 | _ | _ | |c 2021 |
| 336 | 7 | _ | |a Preprint |b preprint |m preprint |0 PUB:(DE-HGF)25 |s 1709641488_29109 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a WORKING_PAPER |2 ORCID |
| 336 | 7 | _ | |a Electronic Article |0 28 |2 EndNote |
| 336 | 7 | _ | |a preprint |2 DRIVER |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a Output Types/Working Paper |2 DataCite |
| 520 | _ | _ | |a Regular musical activity as a highly-stimulating lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease (AD). This study investigated associations between lifelong regular musical instrument playing, late-life cognitive abilities and brain morphology in older adults. We show that musical activity over the life course is associated with better global cognition, working memory, executive functions, language, and visuospatial abilities accounting for reserve proxies. Playing music is not significantly associated with gray matter volume in regions most affected by aging and AD. Selectively in the musically active participants, multi-domain cognitive abilities were enhanced with preserved gray matter volume in frontal and temporal regions. Our correlational findings suggest that playing a musical instrument may improve the recruitment of existing brain resources to facilitate late-life cognitive capacities. We propose that engaging in regular musical activity could serve as a low-threshold multimodal enrichment strategy that may promote cognitive resilience in advanced age. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 1 |
| 536 | _ | _ | |a 351 - Brain Function (POF4-351) |0 G:(DE-HGF)POF4-351 |c POF4-351 |f POF IV |x 2 |
| 588 | _ | _ | |a Dataset connected to CrossRef |
| 700 | 1 | _ | |a Zarucha, Alexis |0 P:(DE-2719)9001433 |b 1 |
| 700 | 1 | _ | |a Koebe, Theresa |0 P:(DE-2719)9000622 |b 2 |
| 700 | 1 | _ | |a Gaubert, Malo |0 P:(DE-2719)2814314 |b 3 |
| 700 | 1 | _ | |a Höppner, Angela |0 P:(DE-2719)2811981 |b 4 |
| 700 | 1 | _ | |a Fabel, Klaus |0 P:(DE-2719)2000006 |b 5 |
| 700 | 1 | _ | |a Altenstein, Slawek |0 P:(DE-2719)2811720 |b 6 |
| 700 | 1 | _ | |a Bartels, Claudia |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Bürger, Katharina |0 P:(DE-2719)2811351 |b 8 |
| 700 | 1 | _ | |a Dechent, Peter |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Dobisch, Laura |0 P:(DE-2719)2811611 |b 10 |
| 700 | 1 | _ | |a Ewers, Michael |0 P:(DE-2719)9000543 |b 11 |
| 700 | 1 | _ | |a Fliessbach, Klaus |0 P:(DE-2719)2811326 |b 12 |
| 700 | 1 | _ | |a Freiesleben, Silka Dawn |0 P:(DE-HGF)0 |b 13 |
| 700 | 1 | _ | |a Frommann, Ingo |0 P:(DE-2719)2810481 |b 14 |
| 700 | 1 | _ | |a Haynes, John Dylan |0 P:(DE-HGF)0 |b 15 |
| 700 | 1 | _ | |a Janowitz, Daniel |0 P:(DE-HGF)0 |b 16 |
| 700 | 1 | _ | |a Kilimann, Ingo |0 P:(DE-2719)2810394 |b 17 |
| 700 | 1 | _ | |a Kleineidam, Luca |0 P:(DE-2719)2812139 |b 18 |
| 700 | 1 | _ | |a Laske, Christoph |0 P:(DE-2719)2000055 |b 19 |
| 700 | 1 | _ | |a Maier, Franziska |0 P:(DE-HGF)0 |b 20 |
| 700 | 1 | _ | |a Metzger, Coraline |0 P:(DE-2719)9000443 |b 21 |
| 700 | 1 | _ | |a Munk, Mathias H. |0 P:(DE-2719)9001516 |b 22 |
| 700 | 1 | _ | |a Perneczky, Robert |0 P:(DE-2719)2812234 |b 23 |
| 700 | 1 | _ | |a Peters, Oliver |0 P:(DE-2719)2811024 |b 24 |
| 700 | 1 | _ | |a Priller, Josef |0 P:(DE-2719)2811122 |b 25 |
| 700 | 1 | _ | |a Rauchmann, Boris-Stephan |0 P:(DE-HGF)0 |b 26 |
| 700 | 1 | _ | |a Roy, Nina |0 P:(DE-2719)2812341 |b 27 |
| 700 | 1 | _ | |a Scheffler, Klaus |0 P:(DE-HGF)0 |b 28 |
| 700 | 1 | _ | |a Schneider, Anja |0 P:(DE-2719)2812035 |b 29 |
| 700 | 1 | _ | |a Spottke, Annika |0 P:(DE-2719)2811324 |b 30 |
| 700 | 1 | _ | |a Teipel, Stefan J. |0 P:(DE-2719)2000026 |b 31 |
| 700 | 1 | _ | |a Wiltfang, Jens |0 P:(DE-2719)2811317 |b 32 |
| 700 | 1 | _ | |a Wolfsgruber, Steffen |0 P:(DE-2719)2810544 |b 33 |
| 700 | 1 | _ | |a Yakupov, Renat |0 P:(DE-2719)2812398 |b 34 |
| 700 | 1 | _ | |a Duzel, Emrah |0 P:(DE-2719)2000005 |b 35 |
| 700 | 1 | _ | |a Jessen, Frank |0 P:(DE-2719)2000032 |b 36 |
| 700 | 1 | _ | |a Röske, Sandra |0 P:(DE-2719)2810395 |b 37 |
| 700 | 1 | _ | |a Wagner, Michael |0 P:(DE-2719)2000057 |b 38 |
| 700 | 1 | _ | |a Kempermann, Gerd |0 P:(DE-2719)2000011 |b 39 |
| 700 | 1 | _ | |a Wirth, Miranka |0 P:(DE-HGF)0 |b 40 |e Last author |
| 773 | _ | _ | |a 10.1101/2021.09.15.460202 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/162594/files/DZNE-2021-01299_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/162594/files/DZNE-2021-01299_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:162594 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)9000495 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)9001433 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 2 |6 P:(DE-2719)9000622 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 3 |6 P:(DE-2719)2814314 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 4 |6 P:(DE-2719)2811981 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 5 |6 P:(DE-2719)2000006 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 6 |6 P:(DE-2719)2811720 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 7 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 8 |6 P:(DE-2719)2811351 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 10 |6 P:(DE-2719)2811611 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 11 |6 P:(DE-2719)9000543 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 12 |6 P:(DE-2719)2811326 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 14 |6 P:(DE-2719)2810481 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 17 |6 P:(DE-2719)2810394 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 18 |6 P:(DE-2719)2812139 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 19 |6 P:(DE-2719)2000055 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 21 |6 P:(DE-2719)9000443 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 22 |6 P:(DE-2719)9001516 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 23 |6 P:(DE-2719)2812234 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 24 |6 P:(DE-2719)2811024 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 25 |6 P:(DE-2719)2811122 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 27 |6 P:(DE-2719)2812341 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 29 |6 P:(DE-2719)2812035 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 30 |6 P:(DE-2719)2811324 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 31 |6 P:(DE-2719)2000026 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 32 |6 P:(DE-2719)2811317 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 33 |6 P:(DE-2719)2810544 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 34 |6 P:(DE-2719)2812398 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 35 |6 P:(DE-2719)2000005 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 36 |6 P:(DE-2719)2000032 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 37 |6 P:(DE-2719)2810395 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 38 |6 P:(DE-2719)2000057 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 39 |6 P:(DE-2719)2000011 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 40 |6 P:(DE-HGF)0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-353 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-352 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Mechanisms |x 1 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-351 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Brain Function |x 2 |
| 914 | 1 | _ | |y 2021 |
| 920 | 1 | _ | |0 I:(DE-2719)1710011 |k AG Wirth |l Brain Resilience |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1710008 |k AG Donix |l Clinical Planning and Intersite Group |x 1 |
| 920 | 1 | _ | |0 I:(DE-2719)1740002 |k AG White |l Imaging Platfrom (Dresden) |x 2 |
| 920 | 1 | _ | |0 I:(DE-2719)1811005 |k AG Endres |l Interdisciplinary Dementia Research |x 3 |
| 920 | 1 | _ | |0 I:(DE-2719)1111015 |k Clinical Research (Munich) |l Clinical Research (Munich) |x 4 |
| 920 | 1 | _ | |0 I:(DE-2719)1340009 |k AG Speck |l Linking imaging projects iNET |x 5 |
| 920 | 1 | _ | |0 I:(DE-2719)1110008 |k AG Simons |l Molecular Neurobiology |x 6 |
| 920 | 1 | _ | |0 I:(DE-2719)1011101 |k Patient Studies Bonn |l Patient Studies Bonn |x 7 |
| 920 | 1 | _ | |0 I:(DE-2719)1011201 |k AG Wagner |l Neuropsychology |x 8 |
| 920 | 1 | _ | |0 I:(DE-2719)1510100 |k AG Teipel |l Clinical Dementia Research (Rostock /Greifswald) |x 9 |
| 920 | 1 | _ | |0 I:(DE-2719)1240005 |k Core ICRU |l Core ICRU |x 10 |
| 920 | 1 | _ | |0 I:(DE-2719)1210000 |k AG Gasser |l Parkinson Genetics |x 11 |
| 920 | 1 | _ | |0 I:(DE-2719)5000007 |k AG Priller |l Translational Neuropsychiatry |x 12 |
| 920 | 1 | _ | |0 I:(DE-2719)1011401 |k Clinical Research Platform (CRP) |l Clinical Research Platform (CRP) |x 13 |
| 920 | 1 | _ | |0 I:(DE-2719)1011305 |k AG Schneider |l Translational Dementia Research (Bonn) |x 14 |
| 920 | 1 | _ | |0 I:(DE-2719)1011001 |k AG Klockgether |l Patient Studies |x 15 |
| 920 | 1 | _ | |0 I:(DE-2719)1410006 |k AG Wiltfang |l Molecular biomarkers for predictive diagnostics of neurodegenerative diseases |x 16 |
| 920 | 1 | _ | |0 I:(DE-2719)5000006 |k AG Düzel |l Clinical Neurophysiology and Memory |x 17 |
| 920 | 1 | _ | |0 I:(DE-2719)1011102 |k AG Jessen |l Clinical Alzheimer’s Disease Research |x 18 |
| 920 | 1 | _ | |0 I:(DE-2719)1710001 |k AG Kempermann |l Adult Neurogenesis |x 19 |
| 980 | _ | _ | |a preprint |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1710011 |
| 980 | _ | _ | |a I:(DE-2719)1710008 |
| 980 | _ | _ | |a I:(DE-2719)1740002 |
| 980 | _ | _ | |a I:(DE-2719)1811005 |
| 980 | _ | _ | |a I:(DE-2719)1111015 |
| 980 | _ | _ | |a I:(DE-2719)1340009 |
| 980 | _ | _ | |a I:(DE-2719)1110008 |
| 980 | _ | _ | |a I:(DE-2719)1011101 |
| 980 | _ | _ | |a I:(DE-2719)1011201 |
| 980 | _ | _ | |a I:(DE-2719)1510100 |
| 980 | _ | _ | |a I:(DE-2719)1240005 |
| 980 | _ | _ | |a I:(DE-2719)1210000 |
| 980 | _ | _ | |a I:(DE-2719)5000007 |
| 980 | _ | _ | |a I:(DE-2719)1011401 |
| 980 | _ | _ | |a I:(DE-2719)1011305 |
| 980 | _ | _ | |a I:(DE-2719)1011001 |
| 980 | _ | _ | |a I:(DE-2719)1410006 |
| 980 | _ | _ | |a I:(DE-2719)5000006 |
| 980 | _ | _ | |a I:(DE-2719)1011102 |
| 980 | _ | _ | |a I:(DE-2719)1710001 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|