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@ARTICLE{MelovanLent:162628,
author = {Melo van Lent, Debora and O'Donnell, Adrienne and Beiser,
Alexa S and Vasan, Ramachandran S and DeCarli, Charles S and
Scarmeas, Nikolaos and Wagner, Michael and Jacques, Paul F
and Seshadri, Sudha and Himali, Jayandra J and Pase, Matthew
P},
title = {{M}ind {D}iet {A}dherence and {C}ognitive {P}erformance in
the {F}ramingham {H}eart {S}tudy.},
journal = {Journal of Alzheimer's disease},
volume = {82},
number = {2},
issn = {1875-8908},
address = {Amsterdam},
publisher = {IOS Press},
reportid = {DZNE-2021-01324},
pages = {827 - 839},
year = {2021},
abstract = {Adherence to the Mediterranean-DASH for Neurodegenerative
Delay (MIND) diet has previously been associated with
cognitive decline and dementia. To our knowledge, no prior
study has investigated the association between the MIND diet
and measures of brain volume, silent brain infarcts (SBIs),
or brain atrophy.We evaluated whether adherence to the MIND
diet associated with superior cognitive function, larger
brain volumes, fewer SBIs, and less cognitive decline in the
community-based Framingham Heart Study.2,092 participants
(mean±SD, age 61±9) completed Food Frequency
Questionnaires, averaged across a maximum of 3-time points
(examination cycles 5, 6, and 7), cognitive testing at
examination cycle 7 (present study baseline: 1998-2001) and
after a mean±SD of 6.6±1.1 years from baseline (n =
1,584). A subset of participants also completed brain
magnetic resonance imaging (MRI) at examination cycle 7 (n =
1,904). In addition, participants with dementia, stroke, and
other relevant neurological diseases such as significant
head trauma, subdural hematoma, or multiple sclerosis were
excluded from the analyses.Higher MIND diet scores were
associated with better global cognitive function
(β±SE,+0.03SD±0.01; p = 0.004), verbal memory, visual
memory, processing speed, verbal comprehension/reasoning,
and with larger total brain volume (TBV) following
adjustments for clinical, lifestyle and demographic
covariates, but not with other brain MRI measures (i.e.,
hippocampal volume, lateral ventricular volume, white matter
hyperintensity volume, and SBIs) or cognitive decline.Higher
MIND diet scores associated with better cognitive
performance and larger TBV at baseline, but not with
cognitive decline. Clinical trials are needed to ascertain
whether adopting the MIND diet affects trajectories of
cognitive decline.},
keywords = {Aged / Asymptomatic Diseases / Brain: diagnostic imaging /
Brain: pathology / Brain Infarction: diagnosis / Brain
Infarction: epidemiology / Cognition: physiology / Cognitive
Dysfunction: epidemiology / Cognitive Dysfunction:
prevention $\&$ control / Diet, Mediterranean: psychology /
Diet, Mediterranean: statistics $\&$ numerical data / Female
/ Humans / Longitudinal Studies / Magnetic Resonance
Imaging: methods / Male / Middle Aged / Neuropsychological
Tests / Organ Size / Patient Compliance: psychology /
Patient Compliance: statistics $\&$ numerical data /
Treatment Outcome / Apolipoprotein ɛ4 (Other) / MIND diet
(Other) / brain volume (Other) / cognition (Other) / dietary
pattern (Other) / framingham heart study (Other) / silent
brain infarcts (Other)},
cin = {AG Wagner / AG Klockgether},
ddc = {610},
cid = {I:(DE-2719)1011201 / I:(DE-2719)1011001},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:34092629},
doi = {10.3233/JAD-201238},
url = {https://pub.dzne.de/record/162628},
}