TY  - JOUR
AU  - Vöglein, Jonathan
AU  - Kostova, Irena
AU  - Arzberger, Thomas
AU  - Noachtar, Soheyl
AU  - Dieterich, Marianne
AU  - Herms, Jochen
AU  - Schmitz, Peer
AU  - Ruf, Viktoria
AU  - Windl, Otto
AU  - Roeber, Sigrun
AU  - Simons, Mikael
AU  - Höglinger, Günter
AU  - Danek, Adrian
AU  - Giese, Armin
AU  - Levin, Johannes
TI  - Seizure prevalence in neurodegenerative diseases-a study of autopsy proven cases.
JO  - European journal of neurology
VL  - 29
IS  - 1
SN  - 1351-5101
CY  - Oxford
PB  - Blackwell Science
M1  - DZNE-2021-01416
SP  - 12-18
PY  - 2022
N1  - ISSN 1468-1331 not unique: **2 hits**. (CC BY-NC)
AB  - Knowledge about the seizure prevalence in the whole symptomatic course, from disease onset to death, in neurodegenerative diseases (ND) is lacking. Therefore, the aim was to investigate seizure prevalence and associated clinical implications in neuropathologically diagnosed ND.Clinical records of cases from the Neurobiobank Munich, Germany, were analyzed. Neuropathological diagnoses of the assessed cases included Alzheimer disease (AD), corticobasal degeneration (CBD), frontotemporal lobar degeneration (FTLD), Lewy body disease (LBD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Seizure prevalence during the whole symptomatic disease phase was assessed and compared amongst ND. Associations between first clinical symptom and seizure prevalence and between seizures and disease duration were examined.In all, 454 patients with neuropathologically diagnosed ND and with available and meaningful clinical records were investigated (AD, n = 144; LBD, n = 103; PSP, n = 93; FTLD, n = 53; MSA, n = 36; CBD, n = 25). Seizure prevalence was 31.3
KW  - Autopsy
KW  - Humans
KW  - Multiple System Atrophy: epidemiology
KW  - Multiple System Atrophy: pathology
KW  - Prevalence
KW  - Seizures: epidemiology
KW  - Supranuclear Palsy, Progressive: diagnosis
KW  - Supranuclear Palsy, Progressive: epidemiology
KW  - Alzheimer disease (Other)
KW  - epilepsy (Other)
KW  - neurodegenerative diseases (Other)
KW  - seizure prevalence (Other)
KW  - seizures (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34472165
DO  - DOI:10.1111/ene.15089
UR  - https://pub.dzne.de/record/162760
ER  -