%0 Journal Article
%A von Hoff, Katja
%A Haberler, Christine
%A Schmitt-Hoffner, Felix
%A Schepke, Elizabeth
%A de Rojas, Teresa
%A Jacobs, Sandra
%A Zapotocky, Michal
%A Sumerauer, David
%A Perek-Polnik, Marta
%A Dufour, Christelle
%A van Vuurden, Dannis
%A Slavc, Irene
%A Gojo, Johannes
%A Pickles, Jessica C
%A Gerber, Nicolas U
%A Massimino, Maura
%A Gil-da-Costa, Maria Joao
%A Garami, Miklos
%A Kumirova, Ella
%A Sehested, Astrid
%A Scheie, David
%A Cruz, Ofelia
%A Moreno, Lucas
%A Cho, Jaeho
%A Zeller, Bernward
%A Bovenschen, Niels
%A Grotzer, Michael
%A Alderete, Daniel
%A Snuderl, Matija
%A Zheludkova, Olga
%A Golanov, Andrey
%A Okonechnikov, Konstantin
%A Mynarek, Martin
%A Juhnke, Björn Ole
%A Rutkowski, Stefan
%A Schüller, Ulrich
%A Pizer, Barry
%A von Zezschwitz, Barbara
%A Kwiecien, Robert
%A Wechsung, Maximilian
%A Konietschke, Frank
%A Hwang, Eugene I
%A Sturm, Dominik
%A Pfister, Stefan M
%A von Deimling, Andreas
%A Rushing, Elisabeth J
%A Ryzhova, Marina
%A Hauser, Peter
%A Łastowska, Maria
%A Wesseling, Pieter
%A Giangaspero, Felice
%A Hawkins, Cynthia
%A Figarella-Branger, Dominique
%A Eberhart, Charles
%A Burger, Peter
%A Gessi, Marco
%A Korshunov, Andrey
%A Jacques, Tom S
%A Capper, David
%A Pietsch, Torsten
%A Kool, Marcel
%T Therapeutic implications of improved molecular diagnostics for rare CNS embryonal tumor entities: results of an international, retrospective study.
%J Neuro-Oncology
%V 23
%N 9
%@ 1523-5866
%C Oxford
%I Oxford Univ. Press
%M DZNE-2021-01455
%P 1597 - 1611
%D 2021
%X Only few data are available on treatment-associated behavior of distinct rare CNS embryonal tumor entities previously treated as 'CNS-primitive neuroectodermal tumors' (CNS-PNET). Respective data on specific entities, including CNS neuroblastoma, FOXR2 activated (CNS NB-FOXR2), and embryonal tumors with multilayered rosettes (ETMR) are needed for development of differentiated treatment strategies.Within this retrospective, international study, tumor samples of clinically well-annotated patients with the original diagnosis of CNS-PNET were analyzed using DNA methylation arrays (n = 307). Additional cases (n = 66) with DNA methylation pattern of CNS NB-FOXR2 were included irrespective of initial histological diagnosis. Pooled clinical data (n = 292) were descriptively analyzed.DNA methylation profiling of 'CNS-PNET' classified 58 (19
%K Brain Neoplasms: diagnosis
%K Brain Neoplasms: genetics
%K Brain Neoplasms: therapy
%K Central Nervous System Neoplasms: diagnosis
%K Central Nervous System Neoplasms: genetics
%K Central Nervous System Neoplasms: therapy
%K Forkhead Transcription Factors
%K Humans
%K Neoplasms, Germ Cell and Embryonal: diagnosis
%K Neoplasms, Germ Cell and Embryonal: genetics
%K Neoplasms, Germ Cell and Embryonal: therapy
%K Neuroectodermal Tumors, Primitive: diagnosis
%K Neuroectodermal Tumors, Primitive: genetics
%K Neuroectodermal Tumors, Primitive: therapy
%K Pathology, Molecular
%K Retrospective Studies
%K CNS NB-FOXR2 (Other)
%K CNS embryonal tumor (Other)
%K CNS-PNET (Other)
%K DNA methylation profiling (Other)
%K ETMR (Other)
%K FOXR2 protein, human (NLM Chemicals)
%K Forkhead Transcription Factors (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34077956
%2 pmc:PMC8408859
%R 10.1093/neuonc/noab136
%U https://pub.dzne.de/record/162800