TY  - JOUR
AU  - von Hoff, Katja
AU  - Haberler, Christine
AU  - Schmitt-Hoffner, Felix
AU  - Schepke, Elizabeth
AU  - de Rojas, Teresa
AU  - Jacobs, Sandra
AU  - Zapotocky, Michal
AU  - Sumerauer, David
AU  - Perek-Polnik, Marta
AU  - Dufour, Christelle
AU  - van Vuurden, Dannis
AU  - Slavc, Irene
AU  - Gojo, Johannes
AU  - Pickles, Jessica C
AU  - Gerber, Nicolas U
AU  - Massimino, Maura
AU  - Gil-da-Costa, Maria Joao
AU  - Garami, Miklos
AU  - Kumirova, Ella
AU  - Sehested, Astrid
AU  - Scheie, David
AU  - Cruz, Ofelia
AU  - Moreno, Lucas
AU  - Cho, Jaeho
AU  - Zeller, Bernward
AU  - Bovenschen, Niels
AU  - Grotzer, Michael
AU  - Alderete, Daniel
AU  - Snuderl, Matija
AU  - Zheludkova, Olga
AU  - Golanov, Andrey
AU  - Okonechnikov, Konstantin
AU  - Mynarek, Martin
AU  - Juhnke, Björn Ole
AU  - Rutkowski, Stefan
AU  - Schüller, Ulrich
AU  - Pizer, Barry
AU  - von Zezschwitz, Barbara
AU  - Kwiecien, Robert
AU  - Wechsung, Maximilian
AU  - Konietschke, Frank
AU  - Hwang, Eugene I
AU  - Sturm, Dominik
AU  - Pfister, Stefan M
AU  - von Deimling, Andreas
AU  - Rushing, Elisabeth J
AU  - Ryzhova, Marina
AU  - Hauser, Peter
AU  - Łastowska, Maria
AU  - Wesseling, Pieter
AU  - Giangaspero, Felice
AU  - Hawkins, Cynthia
AU  - Figarella-Branger, Dominique
AU  - Eberhart, Charles
AU  - Burger, Peter
AU  - Gessi, Marco
AU  - Korshunov, Andrey
AU  - Jacques, Tom S
AU  - Capper, David
AU  - Pietsch, Torsten
AU  - Kool, Marcel
TI  - Therapeutic implications of improved molecular diagnostics for rare CNS embryonal tumor entities: results of an international, retrospective study.
JO  - Neuro-Oncology
VL  - 23
IS  - 9
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2021-01455
SP  - 1597 - 1611
PY  - 2021
AB  - Only few data are available on treatment-associated behavior of distinct rare CNS embryonal tumor entities previously treated as 'CNS-primitive neuroectodermal tumors' (CNS-PNET). Respective data on specific entities, including CNS neuroblastoma, FOXR2 activated (CNS NB-FOXR2), and embryonal tumors with multilayered rosettes (ETMR) are needed for development of differentiated treatment strategies.Within this retrospective, international study, tumor samples of clinically well-annotated patients with the original diagnosis of CNS-PNET were analyzed using DNA methylation arrays (n = 307). Additional cases (n = 66) with DNA methylation pattern of CNS NB-FOXR2 were included irrespective of initial histological diagnosis. Pooled clinical data (n = 292) were descriptively analyzed.DNA methylation profiling of 'CNS-PNET' classified 58 (19
KW  - Brain Neoplasms: diagnosis
KW  - Brain Neoplasms: genetics
KW  - Brain Neoplasms: therapy
KW  - Central Nervous System Neoplasms: diagnosis
KW  - Central Nervous System Neoplasms: genetics
KW  - Central Nervous System Neoplasms: therapy
KW  - Forkhead Transcription Factors
KW  - Humans
KW  - Neoplasms, Germ Cell and Embryonal: diagnosis
KW  - Neoplasms, Germ Cell and Embryonal: genetics
KW  - Neoplasms, Germ Cell and Embryonal: therapy
KW  - Neuroectodermal Tumors, Primitive: diagnosis
KW  - Neuroectodermal Tumors, Primitive: genetics
KW  - Neuroectodermal Tumors, Primitive: therapy
KW  - Pathology, Molecular
KW  - Retrospective Studies
KW  - CNS NB-FOXR2 (Other)
KW  - CNS embryonal tumor (Other)
KW  - CNS-PNET (Other)
KW  - DNA methylation profiling (Other)
KW  - ETMR (Other)
KW  - FOXR2 protein, human (NLM Chemicals)
KW  - Forkhead Transcription Factors (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:34077956
C2  - pmc:PMC8408859
DO  - DOI:10.1093/neuonc/noab136
UR  - https://pub.dzne.de/record/162800
ER  -