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@ARTICLE{Heinzel:162813,
      author       = {Heinzel, Sebastian and Aho, Velma T E and Suenkel, Ulrike
                      and von Thaler, Anna-Katharina and Schulte, Claudia and
                      Deuschle, Christian and Paulin, Lars and Hantunen, Sari and
                      Brockmann, Kathrin and Eschweiler, Gerhard W and Maetzler,
                      Walter and Berg, Daniela and Auvinen, Petri and Scheperjans,
                      Filip},
      title        = {{G}ut {M}icrobiome {S}ignatures of {R}isk and {P}rodromal
                      {M}arkers of {P}arkinson {D}isease.},
      journal      = {Annals of neurology},
      volume       = {90},
      number       = {3},
      issn         = {1531-8249},
      address      = {Hoboken, NJ},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2021-01468},
      pages        = {E1-E12},
      year         = {2021},
      abstract     = {Alterations of the gut microbiome in Parkinson disease (PD)
                      have been repeatedly demonstrated. However, little is known
                      about whether such alterations precede disease onset and how
                      they relate to risk and prodromal markers of PD. We
                      investigated associations of these features with gut
                      microbiome composition.Established risk and prodromal
                      markers of PD as well as factors related to diet/lifestyle,
                      bowel function, and medication were studied in relation to
                      bacterial α-/β-diversity, enterotypes, and differential
                      abundance in stool samples of 666 elderly TREND (Tübingen
                      Evaluation of Risk Factors for Early Detection of
                      Neurodegeneration) study participants.Among risk and
                      prodromal markers, physical inactivity, occupational solvent
                      exposure, and constipation showed associations with
                      α-diversity. Physical inactivity, sex, constipation,
                      possible rapid eye movement sleep behavior disorder (RBD),
                      and smoking were associated with β-diversity. Subthreshold
                      parkinsonism and physical inactivity showed an interaction
                      effect. Among other factors, age and urate-lowering
                      medication were associated with α- and β-diversity.
                      Constipation was highest in individuals with the
                      Firmicutes-enriched enterotype, and physical inactivity was
                      most frequent in the Bacteroides-enriched enterotype.
                      Constipation was lowest and subthreshold parkinsonism least
                      frequent in individuals with the Prevotella-enriched
                      enterotype. Differentially abundant taxa were linked to
                      constipation, physical inactivity, possible RBD, smoking,
                      and subthreshold parkinsonism. Substantia nigra
                      hyperechogenicity, olfactory loss, depression, orthostatic
                      hypotension, urinary/erectile dysfunction, PD family
                      history, and the prodromal PD probability showed no
                      significant microbiome associations.Several risk and
                      prodromal markers of PD are associated with gut microbiome
                      composition. However, the impact of the gut microbiome on PD
                      risk and potential microbiome-dependent subtypes in the
                      prodrome of PD need further investigation based on
                      prospective clinical and (multi)omics data in incident PD
                      cases. ANN NEUROL 2021;90:E1-E12.},
      subtyp        = {Erratum/Correction},
      cin          = {AG Berg ; AG Berg / Biobanking Facility Tübingen / AG
                      Gasser 1},
      ddc          = {610},
      cid          = {I:(DE-2719)5000055 / I:(DE-2719)1240004 /
                      I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34021620},
      doi          = {10.1002/ana.26128},
      url          = {https://pub.dzne.de/record/162813},
}