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| Home > Publications Database > LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies. > print |
| 001 | 162869 | ||
| 005 | 20230915092412.0 | ||
| 024 | 7 | _ | |a 10.15252/emmm.202114745 |2 doi |
| 024 | 7 | _ | |a pmid:34309222 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC8422075 |2 pmc |
| 024 | 7 | _ | |a 1715-4684 |2 ISSN |
| 024 | 7 | _ | |a 1757-4676 |2 ISSN |
| 024 | 7 | _ | |a 1757-4684 |2 ISSN |
| 024 | 7 | _ | |a altmetric:110478633 |2 altmetric |
| 037 | _ | _ | |a DZNE-2021-01524 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Emmenegger, Marc |0 0000-0002-6073-8811 |b 0 |
| 245 | _ | _ | |a LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies. |
| 260 | _ | _ | |a Heidelberg |c 2021 |b EMBO Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1655469967_22303 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a (CC BY) |
| 520 | _ | _ | |a While the initial pathology of Parkinson's disease and other α-synucleinopathies is often confined to circumscribed brain regions, it can spread and progressively affect adjacent and distant brain locales. This process may be controlled by cellular receptors of α-synuclein fibrils, one of which was proposed to be the LAG3 immune checkpoint molecule. Here, we analysed the expression pattern of LAG3 in human and mouse brains. Using a variety of methods and model systems, we found no evidence for LAG3 expression by neurons. While we confirmed that LAG3 interacts with α-synuclein fibrils, the specificity of this interaction appears limited. Moreover, overexpression of LAG3 in cultured human neural cells did not cause any worsening of α-synuclein pathology ex vivo. The overall survival of A53T α-synuclein transgenic mice was unaffected by LAG3 depletion, and the seeded induction of α-synuclein lesions in hippocampal slice cultures was unaffected by LAG3 knockout. These data suggest that the proposed role of LAG3 in the spreading of α-synucleinopathies is not universally valid. |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a LAG3 |2 Other |
| 650 | _ | 7 | |a neurodegeneration |2 Other |
| 650 | _ | 7 | |a prionoids |2 Other |
| 650 | _ | 7 | |a α-synuclein |2 Other |
| 650 | _ | 7 | |a alpha-Synuclein |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Transgenic |2 MeSH |
| 650 | _ | 2 | |a Neurons |2 MeSH |
| 650 | _ | 2 | |a Parkinson Disease |2 MeSH |
| 650 | _ | 2 | |a Synucleinopathies |2 MeSH |
| 650 | _ | 2 | |a alpha-Synuclein: genetics |2 MeSH |
| 700 | 1 | _ | |a De Cecco, Elena |0 0000-0002-0148-2596 |b 1 |
| 700 | 1 | _ | |a Hruska-Plochan, Marian |0 0000-0002-9253-4362 |b 2 |
| 700 | 1 | _ | |a Eninger, Timo |0 P:(DE-2719)2811141 |b 3 |u dzne |
| 700 | 1 | _ | |a Schneider, Matthias M |0 0000-0002-1894-1859 |b 4 |
| 700 | 1 | _ | |a Barth, Melanie |0 P:(DE-2719)2812097 |b 5 |u dzne |
| 700 | 1 | _ | |a Tantardini, Elena |0 0000-0001-9189-3390 |b 6 |
| 700 | 1 | _ | |a de Rossi, Pierre |b 7 |
| 700 | 1 | _ | |a Bacioglu, Mehtap |0 P:(DE-2719)2810940 |b 8 |u dzne |
| 700 | 1 | _ | |a Langston, Rebekah G |b 9 |
| 700 | 1 | _ | |a Kaganovich, Alice |b 10 |
| 700 | 1 | _ | |a Bengoa-Vergniory, Nora |0 0000-0002-3700-0464 |b 11 |
| 700 | 1 | _ | |a Gonzalez-Guerra, Andrès |b 12 |
| 700 | 1 | _ | |a Avar, Merve |0 0000-0003-4665-5558 |b 13 |
| 700 | 1 | _ | |a Heinzer, Daniel |0 0000-0002-3282-4042 |b 14 |
| 700 | 1 | _ | |a Reimann, Regina |b 15 |
| 700 | 1 | _ | |a Häsler, Lisa M |0 P:(DE-2719)2811581 |b 16 |u dzne |
| 700 | 1 | _ | |a Herling, Therese W |b 17 |
| 700 | 1 | _ | |a Matharu, Naunehal S |b 18 |
| 700 | 1 | _ | |a Landeck, Natalie |0 0000-0002-8399-4009 |b 19 |
| 700 | 1 | _ | |a Luk, Kelvin |0 0000-0002-6591-6269 |b 20 |
| 700 | 1 | _ | |a Melki, Ronald |0 0000-0003-0000-7096 |b 21 |
| 700 | 1 | _ | |a Kahle, Philipp J |0 P:(DE-2719)2810803 |b 22 |u dzne |
| 700 | 1 | _ | |a Hornemann, Simone |0 0000-0002-2674-9891 |b 23 |
| 700 | 1 | _ | |a Knowles, Tuomas P J |b 24 |
| 700 | 1 | _ | |a Cookson, Mark R |0 0000-0002-1058-3831 |b 25 |
| 700 | 1 | _ | |a Polymenidou, Magdalini |b 26 |
| 700 | 1 | _ | |a Jucker, Mathias |0 P:(DE-2719)2000010 |b 27 |u dzne |
| 700 | 1 | _ | |a Aguzzi, Adriano |0 0000-0002-0344-6708 |b 28 |
| 773 | _ | _ | |a 10.15252/emmm.202114745 |g Vol. 13, no. 9 |0 PERI:(DE-600)2485479-7 |n 9 |p e14745 |t EMBO molecular medicine |v 13 |y 2021 |x 1757-4684 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/162869/files/DZNE-2021-01524.pdf |
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