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000162884 0247_ $$2doi$$a10.1038/s41590-021-01052-7
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000162884 0247_ $$2ISSN$$a1529-2908
000162884 0247_ $$2ISSN$$a1529-2916
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000162884 037__ $$aDZNE-2021-01539
000162884 041__ $$aEnglish
000162884 082__ $$a610
000162884 1001_ $$aKatzmarski, Natalie$$b0
000162884 245__ $$aTransmission of trained immunity and heterologous resistance to infections across generations.
000162884 260__ $$aLondon$$bSpringer Nature Limited$$c2021
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000162884 520__ $$aIntergenerational inheritance of immune traits linked to epigenetic modifications has been demonstrated in plants and invertebrates. Here we provide evidence for transmission of trained immunity across generations to murine progeny that survived a sublethal systemic infection with Candida albicans or a zymosan challenge. The progeny of trained mice exhibited cellular, developmental, transcriptional and epigenetic changes associated with the bone marrow-resident myeloid effector and progenitor cell compartment. Moreover, the progeny of trained mice showed enhanced responsiveness to endotoxin challenge, alongside improved protection against systemic heterologous Escherichia coli and Listeria monocytogenes infections. Sperm DNA of parental male mice intravenously infected with the fungus C. albicans showed DNA methylation differences linked to immune gene loci. These results provide evidence for inheritance of trained immunity in mammals, enhancing protection against infections.
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000162884 650_2 $$2MeSH$$aAnimals
000162884 650_2 $$2MeSH$$aCandida albicans: immunology
000162884 650_2 $$2MeSH$$aCandida albicans: pathogenicity
000162884 650_2 $$2MeSH$$aCandidiasis: genetics
000162884 650_2 $$2MeSH$$aCandidiasis: immunology
000162884 650_2 $$2MeSH$$aCandidiasis: metabolism
000162884 650_2 $$2MeSH$$aCandidiasis: microbiology
000162884 650_2 $$2MeSH$$aCells, Cultured
000162884 650_2 $$2MeSH$$aDNA Methylation
000162884 650_2 $$2MeSH$$aDisease Models, Animal
000162884 650_2 $$2MeSH$$aEpigenesis, Genetic
000162884 650_2 $$2MeSH$$aEscherichia coli: immunology
000162884 650_2 $$2MeSH$$aEscherichia coli: pathogenicity
000162884 650_2 $$2MeSH$$aEscherichia coli Infections: genetics
000162884 650_2 $$2MeSH$$aEscherichia coli Infections: immunology
000162884 650_2 $$2MeSH$$aEscherichia coli Infections: metabolism
000162884 650_2 $$2MeSH$$aEscherichia coli Infections: microbiology
000162884 650_2 $$2MeSH$$aHeredity
000162884 650_2 $$2MeSH$$aHost-Pathogen Interactions
000162884 650_2 $$2MeSH$$aImmunity, Innate: genetics
000162884 650_2 $$2MeSH$$aListeria monocytogenes: immunology
000162884 650_2 $$2MeSH$$aListeria monocytogenes: pathogenicity
000162884 650_2 $$2MeSH$$aListeriosis: genetics
000162884 650_2 $$2MeSH$$aListeriosis: immunology
000162884 650_2 $$2MeSH$$aListeriosis: metabolism
000162884 650_2 $$2MeSH$$aListeriosis: microbiology
000162884 650_2 $$2MeSH$$aMale
000162884 650_2 $$2MeSH$$aMice, Transgenic
000162884 650_2 $$2MeSH$$aMyeloid Cells: immunology
000162884 650_2 $$2MeSH$$aMyeloid Cells: metabolism
000162884 650_2 $$2MeSH$$aMyeloid Cells: microbiology
000162884 650_2 $$2MeSH$$aSpermatozoa: immunology
000162884 650_2 $$2MeSH$$aSpermatozoa: metabolism
000162884 650_2 $$2MeSH$$aTranscription, Genetic
000162884 7001_ $$00000-0002-9091-1961$$aDomínguez-Andrés, Jorge$$b1
000162884 7001_ $$00000-0002-0754-0099$$aCirovic, Branko$$b2
000162884 7001_ $$00000-0002-2985-0901$$aRenieris, Georgios$$b3
000162884 7001_ $$aCiarlo, Eleonora$$b4
000162884 7001_ $$aLe Roy, Didier$$b5
000162884 7001_ $$aLepikhov, Konstantin$$b6
000162884 7001_ $$00000-0001-5488-6650$$aKattler, Kathrin$$b7
000162884 7001_ $$aGasparoni, Gilles$$b8
000162884 7001_ $$0P:(DE-2719)2812735$$aHändler, Kristian$$b9$$udzne
000162884 7001_ $$0P:(DE-2719)2812165$$aTheis, Heidi$$b10$$udzne
000162884 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc$$b11$$udzne
000162884 7001_ $$avan der Meer, Jos W M$$b12
000162884 7001_ $$00000-0001-6166-9830$$aJoosten, Leo A B$$b13
000162884 7001_ $$00000-0003-0563-7417$$aWalter, Jörn$$b14
000162884 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b15$$udzne
000162884 7001_ $$00000-0002-9358-0109$$aRoger, Thierry$$b16
000162884 7001_ $$00000-0003-4713-3911$$aGiamarellos-Bourboulis, Evangelos J$$b17
000162884 7001_ $$0P:(DE-HGF)0$$aSchlitzer, Andreas$$b18
000162884 7001_ $$00000-0003-2421-6052$$aNetea, Mihai G$$b19
000162884 773__ $$0PERI:(DE-600)2026412-4$$a10.1038/s41590-021-01052-7$$gVol. 22, no. 11, p. 1382 - 1390$$n11$$p1382 - 1390$$tNature immunology$$v22$$x1529-2916$$y2021
000162884 8564_ $$uhttps://pub.dzne.de/record/162884/files/DZNE-2021-01539.pdf
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