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@ARTICLE{Katzmarski:162884,
      author       = {Katzmarski, Natalie and Domínguez-Andrés, Jorge and
                      Cirovic, Branko and Renieris, Georgios and Ciarlo, Eleonora
                      and Le Roy, Didier and Lepikhov, Konstantin and Kattler,
                      Kathrin and Gasparoni, Gilles and Händler, Kristian and
                      Theis, Heidi and Beyer, Marc and van der Meer, Jos W M and
                      Joosten, Leo A B and Walter, Jörn and Schultze, Joachim L
                      and Roger, Thierry and Giamarellos-Bourboulis, Evangelos J
                      and Schlitzer, Andreas and Netea, Mihai G},
      title        = {{T}ransmission of trained immunity and heterologous
                      resistance to infections across generations.},
      journal      = {Nature immunology},
      volume       = {22},
      number       = {11},
      issn         = {1529-2916},
      address      = {London},
      publisher    = {Springer Nature Limited},
      reportid     = {DZNE-2021-01539},
      pages        = {1382 - 1390},
      year         = {2021},
      abstract     = {Intergenerational inheritance of immune traits linked to
                      epigenetic modifications has been demonstrated in plants and
                      invertebrates. Here we provide evidence for transmission of
                      trained immunity across generations to murine progeny that
                      survived a sublethal systemic infection with Candida
                      albicans or a zymosan challenge. The progeny of trained mice
                      exhibited cellular, developmental, transcriptional and
                      epigenetic changes associated with the bone marrow-resident
                      myeloid effector and progenitor cell compartment. Moreover,
                      the progeny of trained mice showed enhanced responsiveness
                      to endotoxin challenge, alongside improved protection
                      against systemic heterologous Escherichia coli and Listeria
                      monocytogenes infections. Sperm DNA of parental male mice
                      intravenously infected with the fungus C. albicans showed
                      DNA methylation differences linked to immune gene loci.
                      These results provide evidence for inheritance of trained
                      immunity in mammals, enhancing protection against
                      infections.},
      keywords     = {Animals / Candida albicans: immunology / Candida albicans:
                      pathogenicity / Candidiasis: genetics / Candidiasis:
                      immunology / Candidiasis: metabolism / Candidiasis:
                      microbiology / Cells, Cultured / DNA Methylation / Disease
                      Models, Animal / Epigenesis, Genetic / Escherichia coli:
                      immunology / Escherichia coli: pathogenicity / Escherichia
                      coli Infections: genetics / Escherichia coli Infections:
                      immunology / Escherichia coli Infections: metabolism /
                      Escherichia coli Infections: microbiology / Heredity /
                      Host-Pathogen Interactions / Immunity, Innate: genetics /
                      Listeria monocytogenes: immunology / Listeria monocytogenes:
                      pathogenicity / Listeriosis: genetics / Listeriosis:
                      immunology / Listeriosis: metabolism / Listeriosis:
                      microbiology / Male / Mice, Transgenic / Myeloid Cells:
                      immunology / Myeloid Cells: metabolism / Myeloid Cells:
                      microbiology / Spermatozoa: immunology / Spermatozoa:
                      metabolism / Transcription, Genetic},
      cin          = {Schultze - PRECISE / AG Beyer / $R\&D$ PRECISE},
      ddc          = {610},
      cid          = {I:(DE-2719)1013031 / I:(DE-2719)1013035 /
                      I:(DE-2719)5000031},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 351
                      - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34663978},
      doi          = {10.1038/s41590-021-01052-7},
      url          = {https://pub.dzne.de/record/162884},
}