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001     162884
005     20240109144107.0
024 7 _ |a 10.1038/s41590-021-01052-7
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024 7 _ |a pmid:34663978
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024 7 _ |a 1529-2908
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024 7 _ |a 1529-2916
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037 _ _ |a DZNE-2021-01539
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Katzmarski, Natalie
|b 0
245 _ _ |a Transmission of trained immunity and heterologous resistance to infections across generations.
260 _ _ |a London
|c 2021
|b Springer Nature Limited
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Intergenerational inheritance of immune traits linked to epigenetic modifications has been demonstrated in plants and invertebrates. Here we provide evidence for transmission of trained immunity across generations to murine progeny that survived a sublethal systemic infection with Candida albicans or a zymosan challenge. The progeny of trained mice exhibited cellular, developmental, transcriptional and epigenetic changes associated with the bone marrow-resident myeloid effector and progenitor cell compartment. Moreover, the progeny of trained mice showed enhanced responsiveness to endotoxin challenge, alongside improved protection against systemic heterologous Escherichia coli and Listeria monocytogenes infections. Sperm DNA of parental male mice intravenously infected with the fungus C. albicans showed DNA methylation differences linked to immune gene loci. These results provide evidence for inheritance of trained immunity in mammals, enhancing protection against infections.
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Candida albicans: immunology
|2 MeSH
650 _ 2 |a Candida albicans: pathogenicity
|2 MeSH
650 _ 2 |a Candidiasis: genetics
|2 MeSH
650 _ 2 |a Candidiasis: immunology
|2 MeSH
650 _ 2 |a Candidiasis: metabolism
|2 MeSH
650 _ 2 |a Candidiasis: microbiology
|2 MeSH
650 _ 2 |a Cells, Cultured
|2 MeSH
650 _ 2 |a DNA Methylation
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Epigenesis, Genetic
|2 MeSH
650 _ 2 |a Escherichia coli: immunology
|2 MeSH
650 _ 2 |a Escherichia coli: pathogenicity
|2 MeSH
650 _ 2 |a Escherichia coli Infections: genetics
|2 MeSH
650 _ 2 |a Escherichia coli Infections: immunology
|2 MeSH
650 _ 2 |a Escherichia coli Infections: metabolism
|2 MeSH
650 _ 2 |a Escherichia coli Infections: microbiology
|2 MeSH
650 _ 2 |a Heredity
|2 MeSH
650 _ 2 |a Host-Pathogen Interactions
|2 MeSH
650 _ 2 |a Immunity, Innate: genetics
|2 MeSH
650 _ 2 |a Listeria monocytogenes: immunology
|2 MeSH
650 _ 2 |a Listeria monocytogenes: pathogenicity
|2 MeSH
650 _ 2 |a Listeriosis: genetics
|2 MeSH
650 _ 2 |a Listeriosis: immunology
|2 MeSH
650 _ 2 |a Listeriosis: metabolism
|2 MeSH
650 _ 2 |a Listeriosis: microbiology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice, Transgenic
|2 MeSH
650 _ 2 |a Myeloid Cells: immunology
|2 MeSH
650 _ 2 |a Myeloid Cells: metabolism
|2 MeSH
650 _ 2 |a Myeloid Cells: microbiology
|2 MeSH
650 _ 2 |a Spermatozoa: immunology
|2 MeSH
650 _ 2 |a Spermatozoa: metabolism
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650 _ 2 |a Transcription, Genetic
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700 1 _ |a Domínguez-Andrés, Jorge
|0 0000-0002-9091-1961
|b 1
700 1 _ |a Cirovic, Branko
|0 0000-0002-0754-0099
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700 1 _ |a Renieris, Georgios
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700 1 _ |a Ciarlo, Eleonora
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700 1 _ |a Le Roy, Didier
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700 1 _ |a Lepikhov, Konstantin
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700 1 _ |a Kattler, Kathrin
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700 1 _ |a Gasparoni, Gilles
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700 1 _ |a Händler, Kristian
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700 1 _ |a Theis, Heidi
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700 1 _ |a Beyer, Marc
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700 1 _ |a van der Meer, Jos W M
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700 1 _ |a Joosten, Leo A B
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700 1 _ |a Walter, Jörn
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700 1 _ |a Schultze, Joachim L
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700 1 _ |a Roger, Thierry
|0 0000-0002-9358-0109
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700 1 _ |a Giamarellos-Bourboulis, Evangelos J
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700 1 _ |a Schlitzer, Andreas
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700 1 _ |a Netea, Mihai G
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773 _ _ |a 10.1038/s41590-021-01052-7
|g Vol. 22, no. 11, p. 1382 - 1390
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|n 11
|p 1382 - 1390
|t Nature immunology
|v 22
|y 2021
|x 1529-2916
856 4 _ |u https://pub.dzne.de/record/162884/files/DZNE-2021-01539.pdf
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