000162906 001__ 162906
000162906 005__ 20240306115244.0
000162906 0247_ $$2doi$$a10.1016/j.celrep.2021.109797
000162906 0247_ $$2pmid$$apmid:34610315
000162906 0247_ $$2ISSN$$a2211-1247
000162906 0247_ $$2ISSN$$a2639-1856
000162906 0247_ $$2altmetric$$aaltmetric:114655448
000162906 037__ $$aDZNE-2021-01561
000162906 041__ $$aEnglish
000162906 082__ $$a610
000162906 1001_ $$aBorgmeyer, Maximilian$$b0
000162906 245__ $$aMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment.
000162906 260__ $$a[New York, NY]$$bElsevier$$c2021
000162906 3367_ $$2DRIVER$$aarticle
000162906 3367_ $$2DataCite$$aOutput Types/Journal article
000162906 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1709641751_29111
000162906 3367_ $$2BibTeX$$aARTICLE
000162906 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000162906 3367_ $$00$$2EndNote$$aJournal Article
000162906 500__ $$aCC BY-NC-ND
000162906 520__ $$aMembrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal transduction from the same sample. Based on this workflow, we generate hypotheses about novel mechanisms underlying complex changes in synaptic connectivity elicited by environmental stimuli. As a proof of principle, this approach reveals that in mice exposed to an enriched environment, reduced endocannabinoid synthesis and signaling is linked to increased surface expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) in a subset of Cannabinoid-receptor 1 positive synapses. This mechanism regulates synaptic strength in an input-specific manner. Thus, we establish a compartment-specific multiomics workflow that is suitable to extract information from complex lipid and protein networks involved in synaptic function and plasticity.
000162906 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000162906 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000162906 650_7 $$2Other$$aLipidomics
000162906 650_7 $$2Other$$aendocannabinoid signaling
000162906 650_7 $$2Other$$aenriched environment
000162906 650_7 $$2Other$$amultiomics
000162906 650_7 $$2Other$$asynaptic junctions
000162906 650_2 $$2MeSH$$aAmidohydrolases: metabolism
000162906 650_2 $$2MeSH$$aAnimals
000162906 650_2 $$2MeSH$$aChromatography, High Pressure Liquid
000162906 650_2 $$2MeSH$$aEndocannabinoids: metabolism
000162906 650_2 $$2MeSH$$aHippocampus: cytology
000162906 650_2 $$2MeSH$$aHippocampus: metabolism
000162906 650_2 $$2MeSH$$aLipid Metabolism: genetics
000162906 650_2 $$2MeSH$$aLipids: analysis
000162906 650_2 $$2MeSH$$aMale
000162906 650_2 $$2MeSH$$aMice
000162906 650_2 $$2MeSH$$aMice, Inbred C57BL
000162906 650_2 $$2MeSH$$aMonoacylglycerol Lipases: metabolism
000162906 650_2 $$2MeSH$$aProteome: analysis
000162906 650_2 $$2MeSH$$aProteomics: methods
000162906 650_2 $$2MeSH$$aRats
000162906 650_2 $$2MeSH$$aRats, Wistar
000162906 650_2 $$2MeSH$$aReceptors, AMPA: metabolism
000162906 650_2 $$2MeSH$$aSignal Transduction: genetics
000162906 650_2 $$2MeSH$$aSynapses: metabolism
000162906 650_2 $$2MeSH$$aTandem Mass Spectrometry
000162906 7001_ $$aComan, Cristina$$b1
000162906 7001_ $$aHas, Canan$$b2
000162906 7001_ $$aSchött, Hans-Frieder$$b3
000162906 7001_ $$aLi, Tingting$$b4
000162906 7001_ $$aWesthoff, Philipp$$b5
000162906 7001_ $$aCheung, Yam F H$$b6
000162906 7001_ $$0P:(DE-HGF)0$$aHoffmann, Nils$$b7
000162906 7001_ $$aYuanxiang, PingAn$$b8
000162906 7001_ $$aBehnisch, Thomas$$b9
000162906 7001_ $$aGomes, Guilherme M$$b10
000162906 7001_ $$aDumenieu, Mael$$b11
000162906 7001_ $$aSchweizer, Michaela$$b12
000162906 7001_ $$aChocholoušková, Michaela$$b13
000162906 7001_ $$aHolčapek, Michal$$b14
000162906 7001_ $$aMikhaylova, Marina$$b15
000162906 7001_ $$0P:(DE-2719)2811905$$aKreutz, Michael R$$b16$$udzne
000162906 7001_ $$aAhrends, Robert$$b17
000162906 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2021.109797$$gVol. 37, no. 1, p. 109797 -$$n1$$p109797$$tCell reports$$v37$$x2211-1247$$y2021
000162906 8564_ $$uhttps://pub.dzne.de/record/162906/files/DZNE-2021-01561.pdf$$yOpenAccess
000162906 8564_ $$uhttps://pub.dzne.de/record/162906/files/DZNE-2021-01561.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000162906 909CO $$ooai:pub.dzne.de:162906$$popenaire$$pVDB$$popen_access$$pdnbdelivery$$pdriver
000162906 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811905$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b16$$kDZNE
000162906 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000162906 9141_ $$y2021
000162906 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-03
000162906 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-03
000162906 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-03
000162906 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2021-02-03
000162906 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000162906 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2021-02-03
000162906 915__ $$0LIC:(DE-HGF)CCBYNCNDNV$$2V:(DE-HGF)$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND (No Version)$$bDOAJ$$d2021-02-03
000162906 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCELL REP : 2021$$d2022-11-17
000162906 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-17
000162906 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-17
000162906 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-01-26T13:08:57Z
000162906 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-01-26T13:08:57Z
000162906 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-01-26T13:08:57Z
000162906 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-17
000162906 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-17
000162906 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-17
000162906 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCELL REP : 2021$$d2022-11-17
000162906 9201_ $$0I:(DE-2719)5000006$$kAG Düzel$$lClinical Neurophysiology and Memory$$x0
000162906 980__ $$ajournal
000162906 980__ $$aVDB
000162906 980__ $$aI:(DE-2719)5000006
000162906 980__ $$aUNRESTRICTED
000162906 9801_ $$aFullTexts