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@ARTICLE{Borgmeyer:162906,
      author       = {Borgmeyer, Maximilian and Coman, Cristina and Has, Canan
                      and Schött, Hans-Frieder and Li, Tingting and Westhoff,
                      Philipp and Cheung, Yam F H and Hoffmann, Nils and
                      Yuanxiang, PingAn and Behnisch, Thomas and Gomes, Guilherme
                      M and Dumenieu, Mael and Schweizer, Michaela and
                      Chocholoušková, Michaela and Holčapek, Michal and
                      Mikhaylova, Marina and Kreutz, Michael R and Ahrends,
                      Robert},
      title        = {{M}ultiomics of synaptic junctions reveals altered lipid
                      metabolism and signaling following environmental
                      enrichment.},
      journal      = {Cell reports},
      volume       = {37},
      number       = {1},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-01561},
      pages        = {109797},
      year         = {2021},
      note         = {CC BY-NC-ND},
      abstract     = {Membrane lipids and their metabolism have key functions in
                      neurotransmission. Here we provide a quantitative lipid
                      inventory of mouse and rat synaptic junctions. To this end,
                      we developed a multiomics extraction and analysis workflow
                      to probe the interplay of proteins and lipids in synaptic
                      signal transduction from the same sample. Based on this
                      workflow, we generate hypotheses about novel mechanisms
                      underlying complex changes in synaptic connectivity elicited
                      by environmental stimuli. As a proof of principle, this
                      approach reveals that in mice exposed to an enriched
                      environment, reduced endocannabinoid synthesis and signaling
                      is linked to increased surface expression of
                      α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
                      receptor (AMPAR) in a subset of Cannabinoid-receptor 1
                      positive synapses. This mechanism regulates synaptic
                      strength in an input-specific manner. Thus, we establish a
                      compartment-specific multiomics workflow that is suitable to
                      extract information from complex lipid and protein networks
                      involved in synaptic function and plasticity.},
      keywords     = {Amidohydrolases: metabolism / Animals / Chromatography,
                      High Pressure Liquid / Endocannabinoids: metabolism /
                      Hippocampus: cytology / Hippocampus: metabolism / Lipid
                      Metabolism: genetics / Lipids: analysis / Male / Mice /
                      Mice, Inbred C57BL / Monoacylglycerol Lipases: metabolism /
                      Proteome: analysis / Proteomics: methods / Rats / Rats,
                      Wistar / Receptors, AMPA: metabolism / Signal Transduction:
                      genetics / Synapses: metabolism / Tandem Mass Spectrometry /
                      Lipidomics (Other) / endocannabinoid signaling (Other) /
                      enriched environment (Other) / multiomics (Other) / synaptic
                      junctions (Other)},
      cin          = {AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34610315},
      doi          = {10.1016/j.celrep.2021.109797},
      url          = {https://pub.dzne.de/record/162906},
}