Home > Publications Database > Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment. > print

001     162906
005     20240306115244.0
024 7 _ |a 10.1016/j.celrep.2021.109797
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024 7 _ |a 2639-1856
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037 _ _ |a DZNE-2021-01561
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Borgmeyer, Maximilian
|b 0
245 _ _ |a Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment.
260 _ _ |a [New York, NY]
|c 2021
|b Elsevier
336 7 _ |a article
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500 _ _ |a CC BY-NC-ND
520 _ _ |a Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal transduction from the same sample. Based on this workflow, we generate hypotheses about novel mechanisms underlying complex changes in synaptic connectivity elicited by environmental stimuli. As a proof of principle, this approach reveals that in mice exposed to an enriched environment, reduced endocannabinoid synthesis and signaling is linked to increased surface expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) in a subset of Cannabinoid-receptor 1 positive synapses. This mechanism regulates synaptic strength in an input-specific manner. Thus, we establish a compartment-specific multiomics workflow that is suitable to extract information from complex lipid and protein networks involved in synaptic function and plasticity.
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650 _ 7 |a Lipidomics
|2 Other
650 _ 7 |a endocannabinoid signaling
|2 Other
650 _ 7 |a enriched environment
|2 Other
650 _ 7 |a multiomics
|2 Other
650 _ 7 |a synaptic junctions
|2 Other
650 _ 2 |a Amidohydrolases: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Chromatography, High Pressure Liquid
|2 MeSH
650 _ 2 |a Endocannabinoids: metabolism
|2 MeSH
650 _ 2 |a Hippocampus: cytology
|2 MeSH
650 _ 2 |a Hippocampus: metabolism
|2 MeSH
650 _ 2 |a Lipid Metabolism: genetics
|2 MeSH
650 _ 2 |a Lipids: analysis
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Monoacylglycerol Lipases: metabolism
|2 MeSH
650 _ 2 |a Proteome: analysis
|2 MeSH
650 _ 2 |a Proteomics: methods
|2 MeSH
650 _ 2 |a Rats
|2 MeSH
650 _ 2 |a Rats, Wistar
|2 MeSH
650 _ 2 |a Receptors, AMPA: metabolism
|2 MeSH
650 _ 2 |a Signal Transduction: genetics
|2 MeSH
650 _ 2 |a Synapses: metabolism
|2 MeSH
650 _ 2 |a Tandem Mass Spectrometry
|2 MeSH
700 1 _ |a Coman, Cristina
|b 1
700 1 _ |a Has, Canan
|b 2
700 1 _ |a Schött, Hans-Frieder
|b 3
700 1 _ |a Li, Tingting
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700 1 _ |a Westhoff, Philipp
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700 1 _ |a Cheung, Yam F H
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700 1 _ |a Hoffmann, Nils
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700 1 _ |a Yuanxiang, PingAn
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700 1 _ |a Behnisch, Thomas
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700 1 _ |a Gomes, Guilherme M
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700 1 _ |a Dumenieu, Mael
|b 11
700 1 _ |a Schweizer, Michaela
|b 12
700 1 _ |a Chocholoušková, Michaela
|b 13
700 1 _ |a Holčapek, Michal
|b 14
700 1 _ |a Mikhaylova, Marina
|b 15
700 1 _ |a Kreutz, Michael R
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700 1 _ |a Ahrends, Robert
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773 _ _ |a 10.1016/j.celrep.2021.109797
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