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@ARTICLE{Haussmann:162912,
      author       = {Haussmann, Robert and Homeyer, P. and Haußmann, M. and
                      Brandt, Daniel Moritz and Donix, M. and Puetz, V. and Linn,
                      J.},
      title        = {{I}ntrazerebrale {B}lutungen unter
                      {P}lättchenaggregationshemmung und oraler {A}ntikoagulation
                      bei {P}atienten mit zerebraler {A}myloidangiopathie.},
      journal      = {Der Nervenarzt},
      volume       = {93},
      number       = {6},
      issn         = {1433-0407},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DZNE-2021-01565},
      pages        = {599-604},
      year         = {2022},
      note         = {(CC BY)},
      abstract     = {Oral anticoagulation in patients with cerebral amyloid
                      angiopathy is a therapeutic challenge. The association of
                      cerebral amyloid angiopathy with intracerebral hemorrhage, a
                      high mortality of intracerebral hemorrhage especially under
                      oral anticoagulation and the high risk of recurrent bleeding
                      require a multidisciplinary approach and a thorough
                      risk-benefit analysis. Vitamin K antagonists increase the
                      risk of intracerebral bleeding and the accompanying
                      mortality by $60\%$ and should be avoided if possible or
                      reserved for special clinical situations (e.g. mechanical
                      aortic valve replacement). Treatment with novel oral
                      anticoagulants and antiplatelet drugs also increases the
                      risk of cerebral bleeding and therefore needs a thorough
                      risk-benefit evaluation. An interventional left atrial
                      appendage closure is a promising therapeutic option
                      especially in patients with an absolute arrythmia with
                      atrial fibrillation. Furthermore, other clinical
                      implications in patients with cerebral amyloid angiopathy
                      are the subject of this review of the literature, such as
                      special characteristics after acute ischemic stroke and the
                      necessary secondary prophylaxis, with previous intracerebral
                      hemorrhage and in patients with cognitive deficits.},
      subtyp        = {Review Article},
      keywords     = {Anticoagulants: therapeutic use / Atrial Fibrillation:
                      complications / Atrial Fibrillation: drug therapy / Cerebral
                      Amyloid Angiopathy: complications / Cerebral Amyloid
                      Angiopathy: diagnosis / Cerebral Amyloid Angiopathy: drug
                      therapy / Cerebral Hemorrhage: chemically induced / Cerebral
                      Hemorrhage: complications / Cerebral Hemorrhage: diagnosis /
                      Humans / Ischemic Stroke / Stroke: complications / Cerebral
                      amyloid angiopathy (Other) / Interventional left atrial
                      appendage closure (Other) / Intracerebral hemorrhage (Other)
                      / Oral anticoagulation (Other) / Platelet inhibition
                      (Other)},
      cin          = {AG Donix},
      ddc          = {610},
      cid          = {I:(DE-2719)1710008},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9200694},
      pubmed       = {pmid:34652485},
      doi          = {10.1007/s00115-021-01206-w},
      url          = {https://pub.dzne.de/record/162912},
}