%0 Journal Article
%A Zacharias, Helena U
%A Weihs, Antoine
%A Habes, Mohamad
%A Wittfeld, Katharina
%A Frenzel, Stefan
%A Rashid, Tanweer
%A Stubbe, Beate
%A Obst, Anne
%A Szentkirályi, András
%A Bülow, Robin
%A Berger, Klaus
%A Fietze, Ingo
%A Penzel, Thomas
%A Hosten, Norbert
%A Ewert, Ralf
%A Völzke, Henry
%A Grabe, Hans
%T Association Between Obstructive Sleep Apnea and Brain White Matter Hyperintensities in a Population-Based Cohort in Germany.
%J JAMA network open
%V 4
%N 10
%@ 2574-3805
%C Chicago, Ill.
%I American Medical Association
%M DZNE-2021-01573
%P e2128225
%D 2021
%Z (CC BY)
%X Underlying pathomechanisms of brain white matter hyperintensities (WMHs), commonly observed in older individuals and significantly associated with Alzheimer disease and brain aging, have not yet been fully elucidated. One potential contributing factor to WMH burden is chronic obstructive sleep apnea (OSA), a disorder highly prevalent in the general population with readily available treatment options.To investigate potential associations between OSA and WMH burden.Analyses were conducted in 529 study participants of the Study of Health in Pomerania-Trend baseline (SHIP-Trend-0) study with complete WMH, OSA, and important clinical data available. SHIP-Trend-0 is a general population-based, cross-sectional, observational study to facilitate the investigation of a large spectrum of common risk factors, subclinical disorders, and clinical diseases and their relationships among each other with patient recruitment from Western Pomerania, Germany, starting on September 1, 2008, with data collected until December 31, 2012. Data analysis was performed from February 1, 2019, to January 31, 2021.The apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) were assessed during a single-night, laboratory-based polysomnography measurement.The primary outcome was WMH data automatically segmented from 1.5-T magnetic resonance images.Of 529 study participants (mean [SD] age, 52.15 [13.58] years; 282 female [53
%K Adult
%K Aged
%K Aging: physiology
%K Cohort Studies
%K Cross-Sectional Studies
%K Female
%K Germany: epidemiology
%K Humans
%K Magnetic Resonance Imaging: methods
%K Magnetic Resonance Imaging: statistics & numerical data
%K Male
%K Middle Aged
%K Sleep Apnea, Obstructive: complications
%K Sleep Apnea, Obstructive: diagnostic imaging
%K Sleep Apnea, Obstructive: epidemiology
%K White Matter: abnormalities
%K White Matter: physiopathology
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34609493
%2 pmc:PMC8493431
%R 10.1001/jamanetworkopen.2021.28225
%U https://pub.dzne.de/record/162920