TY  - JOUR
AU  - Zacharias, Helena U
AU  - Weihs, Antoine
AU  - Habes, Mohamad
AU  - Wittfeld, Katharina
AU  - Frenzel, Stefan
AU  - Rashid, Tanweer
AU  - Stubbe, Beate
AU  - Obst, Anne
AU  - Szentkirályi, András
AU  - Bülow, Robin
AU  - Berger, Klaus
AU  - Fietze, Ingo
AU  - Penzel, Thomas
AU  - Hosten, Norbert
AU  - Ewert, Ralf
AU  - Völzke, Henry
AU  - Grabe, Hans
TI  - Association Between Obstructive Sleep Apnea and Brain White Matter Hyperintensities in a Population-Based Cohort in Germany.
JO  - JAMA network open
VL  - 4
IS  - 10
SN  - 2574-3805
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DZNE-2021-01573
SP  - e2128225
PY  - 2021
N1  - (CC BY)
AB  - Underlying pathomechanisms of brain white matter hyperintensities (WMHs), commonly observed in older individuals and significantly associated with Alzheimer disease and brain aging, have not yet been fully elucidated. One potential contributing factor to WMH burden is chronic obstructive sleep apnea (OSA), a disorder highly prevalent in the general population with readily available treatment options.To investigate potential associations between OSA and WMH burden.Analyses were conducted in 529 study participants of the Study of Health in Pomerania-Trend baseline (SHIP-Trend-0) study with complete WMH, OSA, and important clinical data available. SHIP-Trend-0 is a general population-based, cross-sectional, observational study to facilitate the investigation of a large spectrum of common risk factors, subclinical disorders, and clinical diseases and their relationships among each other with patient recruitment from Western Pomerania, Germany, starting on September 1, 2008, with data collected until December 31, 2012. Data analysis was performed from February 1, 2019, to January 31, 2021.The apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) were assessed during a single-night, laboratory-based polysomnography measurement.The primary outcome was WMH data automatically segmented from 1.5-T magnetic resonance images.Of 529 study participants (mean [SD] age, 52.15 [13.58] years; 282 female [53
KW  - Adult
KW  - Aged
KW  - Aging: physiology
KW  - Cohort Studies
KW  - Cross-Sectional Studies
KW  - Female
KW  - Germany: epidemiology
KW  - Humans
KW  - Magnetic Resonance Imaging: methods
KW  - Magnetic Resonance Imaging: statistics & numerical data
KW  - Male
KW  - Middle Aged
KW  - Sleep Apnea, Obstructive: complications
KW  - Sleep Apnea, Obstructive: diagnostic imaging
KW  - Sleep Apnea, Obstructive: epidemiology
KW  - White Matter: abnormalities
KW  - White Matter: physiopathology
LB  - PUB:(DE-HGF)16
C6  - pmid:34609493
C2  - pmc:PMC8493431
DO  - DOI:10.1001/jamanetworkopen.2021.28225
UR  - https://pub.dzne.de/record/162920
ER  -