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@ARTICLE{Jangani:162927,
      author       = {Jangani, Maryam and Vuononvirta, Juho and Yamani, Lamya and
                      Ward, Eleanor and Capasso, Melania and Nadkarni, Suchita and
                      Balkwill, Frances and Marelli-Berg, Federica},
      title        = {{L}oss of m{TORC}2-induced metabolic reprogramming in
                      monocytes uncouples migration and maturation from production
                      of proinflammatory mediators.},
      journal      = {Journal of leukocyte biology},
      volume       = {111},
      number       = {5},
      issn         = {1938-3673},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2021-01579},
      pages        = {967-980},
      year         = {2022},
      note         = {(CC BY)},
      abstract     = {Monocyte migration to the sites of inflammation and
                      maturation into macrophages are key steps for their immune
                      effector function. Here, we show that mechanistic target of
                      rapamycin complex 2 (mTORC2)-dependent Akt activation is
                      instrumental for metabolic reprogramming at the early stages
                      of macrophage-mediated immunity. Despite an increased
                      production of proinflammatory mediators, monocytes lacking
                      expression of the mTORC2 component Rictor fail to
                      efficiently migrate to inflammatory sites and fully mature
                      into macrophages, resulting in reduced inflammatory
                      responses in vivo. The mTORC2-dependent phosphorylation of
                      Akt is instrumental for the enhancement of glycolysis and
                      mitochondrial respiration, required to sustain monocyte
                      maturation and motility. These observations are discussed in
                      the context of therapeutic strategies aimed at selective
                      inhibition of mTORC2 activity.},
      keywords     = {Macrophages: metabolism / Mechanistic Target of Rapamycin
                      Complex 2: metabolism / Monocytes: metabolism /
                      Proto-Oncogene Proteins c-akt: metabolism /
                      Rapamycin-Insensitive Companion of mTOR Protein: metabolism
                      / Sirolimus / cell metabolism (Other) / mTORC2 (Other) /
                      macrophage (Other) / metabolism (Other) / monocyte (Other)},
      cin          = {AG Capasso},
      ddc          = {570},
      cid          = {I:(DE-2719)1013033},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34585416},
      doi          = {10.1002/JLB.1A0920-588R},
      url          = {https://pub.dzne.de/record/162927},
}