% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Prisco:163151,
      author       = {Prisco, Luigi and Deimel, Stephan Hubertus and Yeliseyeva,
                      Hanna and Fiala, André and Tavosanis, Gaia},
      title        = {{T}he anterior paired lateral neuron normalizes
                      odour-evoked activity in the {D}rosophila mushroom body
                      calyx.},
      journal      = {eLife},
      volume       = {10},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {DZNE-2022-00002},
      pages        = {e74172},
      year         = {2021},
      note         = {Grants relevant to the publication: Forschungsgruppe 2705 ,
                      Entschlüsselung eines Gehirn-Schaltkreises: Struktur,
                      Plastizität und Verhaltensfunktion des Pilzkörpers von
                      Drosophila},
      abstract     = {To identify and memorize discrete but similar environmental
                      inputs, the brain needs to distinguish between subtle
                      differences of activity patterns in defined neuronal
                      populations. The Kenyon cells (KCs) of the Drosophila adult
                      mushroom body (MB) respond sparsely to complex olfactory
                      input, a property that is thought to support stimuli
                      discrimination in the MB. To understand how this property
                      emerges, we investigated the role of the inhibitory anterior
                      paired lateral (APL) neuron in the input circuit of the MB,
                      the calyx. Within the calyx, presynaptic boutons of
                      projection neurons (PNs) form large synaptic microglomeruli
                      (MGs) with dendrites of postsynaptic KCs. Combining electron
                      microscopy (EM) data analysis and in vivo calcium imaging,
                      we show that APL, via inhibitory and reciprocal synapses
                      targeting both PN boutons and KC dendrites, normalizes
                      odour-evoked representations in MGs of the calyx. APL
                      response scales with the PN input strength and is
                      regionalized around PN input distribution. Our data indicate
                      that the formation of a sparse code by the KCs requires
                      APL-driven normalization of their MG postsynaptic responses.
                      This work provides experimental insights on how inhibition
                      shapes sensory information representation in a higher brain
                      centre, thereby supporting stimuli discrimination and
                      allowing for efficient associative memory formation.},
      keywords     = {Animals / Calcium: analysis / Drosophila melanogaster:
                      physiology / Female / Male / Microscopy, Confocal /
                      Microscopy, Electron / Mushroom Bodies: physiology /
                      Mushroom Bodies: ultrastructure / Neurons: physiology /
                      Neurons: ultrastructure / Presynaptic Terminals / Smell:
                      physiology / APL (Other) / D. melanogaster (Other) /
                      inhibition (Other) / microglomerulus (Other) / mushroom body
                      (Other) / neuroscience (Other) / pattern separation (Other)
                      / sparse coding (Other) / Calcium (NLM Chemicals)},
      cin          = {AG Tavosanis},
      ddc          = {600},
      cid          = {I:(DE-2719)1013018},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34964714},
      pmc          = {pmc:PMC8741211},
      doi          = {10.7554/eLife.74172},
      url          = {https://pub.dzne.de/record/163151},
}