Home > Publications Database > The anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx. > print

001     163151
005     20230915092416.0
024 7 _ |a 10.7554/eLife.74172
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037 _ _ |a DZNE-2022-00002
041 _ _ |a English
082 _ _ |a 600
100 1 _ |a Prisco, Luigi
|0 P:(DE-2719)2812229
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245 _ _ |a The anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx.
260 _ _ |a Cambridge
|c 2021
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500 _ _ |a Grants relevant to the publication: Forschungsgruppe 2705 , Entschlüsselung eines Gehirn-Schaltkreises: Struktur, Plastizität und Verhaltensfunktion des Pilzkörpers von Drosophila
520 _ _ |a To identify and memorize discrete but similar environmental inputs, the brain needs to distinguish between subtle differences of activity patterns in defined neuronal populations. The Kenyon cells (KCs) of the Drosophila adult mushroom body (MB) respond sparsely to complex olfactory input, a property that is thought to support stimuli discrimination in the MB. To understand how this property emerges, we investigated the role of the inhibitory anterior paired lateral (APL) neuron in the input circuit of the MB, the calyx. Within the calyx, presynaptic boutons of projection neurons (PNs) form large synaptic microglomeruli (MGs) with dendrites of postsynaptic KCs. Combining electron microscopy (EM) data analysis and in vivo calcium imaging, we show that APL, via inhibitory and reciprocal synapses targeting both PN boutons and KC dendrites, normalizes odour-evoked representations in MGs of the calyx. APL response scales with the PN input strength and is regionalized around PN input distribution. Our data indicate that the formation of a sparse code by the KCs requires APL-driven normalization of their MG postsynaptic responses. This work provides experimental insights on how inhibition shapes sensory information representation in a higher brain centre, thereby supporting stimuli discrimination and allowing for efficient associative memory formation.
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650 _ 7 |a APL
|2 Other
650 _ 7 |a D. melanogaster
|2 Other
650 _ 7 |a inhibition
|2 Other
650 _ 7 |a microglomerulus
|2 Other
650 _ 7 |a mushroom body
|2 Other
650 _ 7 |a neuroscience
|2 Other
650 _ 7 |a pattern separation
|2 Other
650 _ 7 |a sparse coding
|2 Other
650 _ 7 |a Calcium
|0 SY7Q814VUP
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Calcium: analysis
|2 MeSH
650 _ 2 |a Drosophila melanogaster: physiology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Microscopy, Confocal
|2 MeSH
650 _ 2 |a Microscopy, Electron
|2 MeSH
650 _ 2 |a Mushroom Bodies: physiology
|2 MeSH
650 _ 2 |a Mushroom Bodies: ultrastructure
|2 MeSH
650 _ 2 |a Neurons: physiology
|2 MeSH
650 _ 2 |a Neurons: ultrastructure
|2 MeSH
650 _ 2 |a Presynaptic Terminals
|2 MeSH
650 _ 2 |a Smell: physiology
|2 MeSH
700 1 _ |a Deimel, Stephan Hubertus
|0 0000-0002-4678-4926
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700 1 _ |a Yeliseyeva, Hanna
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700 1 _ |a Fiala, André
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700 1 _ |a Tavosanis, Gaia
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773 _ _ |a 10.7554/eLife.74172
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787 0 _ |a Tavosanis, Gaia et.al.
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|t APL synapses distribution on PN and KC meshes, primary data, calcium imaging macros and python scripts from Prisco et al.
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