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000163270 0247_ $$2doi$$a10.1016/j.cmet.2022.01.005
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000163270 041__ $$aEnglish
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000163270 1001_ $$0P:(DE-2719)9000937$$aLeiter, Odette$$b0$$eFirst author
000163270 245__ $$aSelenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging.
000163270 260__ $$aCambridge, Mass.$$bCell Press$$c2022
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000163270 520__ $$aAlthough the neurogenesis-enhancing effects of exercise have been extensively studied, the molecular mechanisms underlying this response remain unclear. Here, we propose that this is mediated by the exercise-induced systemic release of the antioxidant selenium transport protein, selenoprotein P (SEPP1). Using knockout mouse models, we confirmed that SEPP1 and its receptor low-density lipoprotein receptor-related protein 8 (LRP8) are required for the exercise-induced increase in adult hippocampal neurogenesis. In vivo selenium infusion increased hippocampal neural precursor cell (NPC) proliferation and adult neurogenesis. Mimicking the effect of exercise through dietary selenium supplementation restored neurogenesis and reversed the cognitive decline associated with aging and hippocampal injury, suggesting potential therapeutic relevance. These results provide a molecular mechanism linking exercise-induced changes in the systemic environment to the activation of quiescent hippocampal NPCs and their subsequent recruitment into the neurogenic trajectory.
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000163270 650_7 $$2Other$$aadult neurogenesis
000163270 650_7 $$2Other$$aaging
000163270 650_7 $$2Other$$adentate gyrus
000163270 650_7 $$2Other$$aendothelin-1
000163270 650_7 $$2Other$$aexercise
000163270 650_7 $$2Other$$ahippocampal lesion
000163270 650_7 $$2Other$$ahippocampus
000163270 650_7 $$2Other$$aneural precursor cell
000163270 650_7 $$2Other$$aneural stem cell
000163270 650_7 $$2Other$$aselenium
000163270 650_2 $$2MeSH$$aAging
000163270 650_2 $$2MeSH$$aAnimals
000163270 650_2 $$2MeSH$$aCell Proliferation
000163270 650_2 $$2MeSH$$aHippocampus
000163270 650_2 $$2MeSH$$aMice
000163270 650_2 $$2MeSH$$aNeural Stem Cells: metabolism
000163270 650_2 $$2MeSH$$aNeurogenesis: physiology
000163270 650_2 $$2MeSH$$aSelenium: metabolism
000163270 650_2 $$2MeSH$$aSelenium: pharmacology
000163270 7001_ $$aZhuo, Zhan$$b1
000163270 7001_ $$0P:(DE-2719)9002271$$aRust, Ruslan$$b2$$udzne
000163270 7001_ $$0P:(DE-2719)9000338$$aWasielewska, Joanna M$$b3
000163270 7001_ $$0P:(DE-2719)9000106$$aGrönnert, Lisa$$b4
000163270 7001_ $$0P:(DE-2719)9002264$$aKowal, Susann$$b5$$udzne
000163270 7001_ $$0P:(DE-2719)2812530$$aOverall, Rupert W$$b6
000163270 7001_ $$0P:(DE-2719)2810887$$aAdusumilli, Vijay S$$b7
000163270 7001_ $$aBlackmore, Daniel G$$b8
000163270 7001_ $$aSouthon, Adam$$b9
000163270 7001_ $$aGanio, Katherine$$b10
000163270 7001_ $$aMcDevitt, Christopher A$$b11
000163270 7001_ $$0P:(DE-2719)2811674$$aRund, Nicole$$b12
000163270 7001_ $$aBrici, David$$b13
000163270 7001_ $$aMudiyan, Imesh Aththanayake$$b14
000163270 7001_ $$aSykes, Alexander M$$b15
000163270 7001_ $$0P:(DE-2719)2810792$$aRünker, Annette E$$b16
000163270 7001_ $$0P:(DE-2719)2810548$$aZocher, Sara$$b17
000163270 7001_ $$aAyton, Scott$$b18
000163270 7001_ $$aBush, Ashley I$$b19
000163270 7001_ $$aBartlett, Perry F$$b20
000163270 7001_ $$aHou, Sheng-Tao$$b21
000163270 7001_ $$0P:(DE-2719)2000011$$aKempermann, Gerd$$b22
000163270 7001_ $$0P:(DE-2719)9000335$$aWalker, Tara L$$b23$$eLast author
000163270 773__ $$0PERI:(DE-600)2174469-5$$a10.1016/j.cmet.2022.01.005$$gVol. 34, no. 3, p. 408 - 423.e8$$n3$$p408 - 423.e8$$tCell metabolism$$v34$$x1550-4131$$y2022
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