TY  - JOUR
AU  - Leiter, Odette
AU  - Zhuo, Zhan
AU  - Rust, Ruslan
AU  - Wasielewska, Joanna M
AU  - Grönnert, Lisa
AU  - Kowal, Susann
AU  - Overall, Rupert W
AU  - Adusumilli, Vijay S
AU  - Blackmore, Daniel G
AU  - Southon, Adam
AU  - Ganio, Katherine
AU  - McDevitt, Christopher A
AU  - Rund, Nicole
AU  - Brici, David
AU  - Mudiyan, Imesh Aththanayake
AU  - Sykes, Alexander M
AU  - Rünker, Annette E
AU  - Zocher, Sara
AU  - Ayton, Scott
AU  - Bush, Ashley I
AU  - Bartlett, Perry F
AU  - Hou, Sheng-Tao
AU  - Kempermann, Gerd
AU  - Walker, Tara L
TI  - Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging.
JO  - Cell metabolism
VL  - 34
IS  - 3
SN  - 1550-4131
CY  - Cambridge, Mass.
PB  - Cell Press
M1  - DZNE-2022-00050
SP  - 408 - 423.e8
PY  - 2022
N1  - (CC BY-NC-ND)
AB  - Although the neurogenesis-enhancing effects of exercise have been extensively studied, the molecular mechanisms underlying this response remain unclear. Here, we propose that this is mediated by the exercise-induced systemic release of the antioxidant selenium transport protein, selenoprotein P (SEPP1). Using knockout mouse models, we confirmed that SEPP1 and its receptor low-density lipoprotein receptor-related protein 8 (LRP8) are required for the exercise-induced increase in adult hippocampal neurogenesis. In vivo selenium infusion increased hippocampal neural precursor cell (NPC) proliferation and adult neurogenesis. Mimicking the effect of exercise through dietary selenium supplementation restored neurogenesis and reversed the cognitive decline associated with aging and hippocampal injury, suggesting potential therapeutic relevance. These results provide a molecular mechanism linking exercise-induced changes in the systemic environment to the activation of quiescent hippocampal NPCs and their subsequent recruitment into the neurogenic trajectory.
KW  - Aging
KW  - Animals
KW  - Cell Proliferation
KW  - Hippocampus
KW  - Mice
KW  - Neural Stem Cells: metabolism
KW  - Neurogenesis: physiology
KW  - Selenium: metabolism
KW  - Selenium: pharmacology
KW  - adult neurogenesis (Other)
KW  - aging (Other)
KW  - dentate gyrus (Other)
KW  - endothelin-1 (Other)
KW  - exercise (Other)
KW  - hippocampal lesion (Other)
KW  - hippocampus (Other)
KW  - neural precursor cell (Other)
KW  - neural stem cell (Other)
KW  - selenium (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35120590
DO  - DOI:10.1016/j.cmet.2022.01.005
UR  - https://pub.dzne.de/record/163270
ER  -