Home > Publications Database > Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging. > print

001     163270
005     20240301115152.0
024 7 _ |a 10.1016/j.cmet.2022.01.005
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024 7 _ |a pmid:35120590
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024 7 _ |a 1550-4131
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024 7 _ |a 1932-7420
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037 _ _ |a DZNE-2022-00050
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Leiter, Odette
|0 P:(DE-2719)9000937
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|e First author
245 _ _ |a Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging.
260 _ _ |a Cambridge, Mass.
|c 2022
|b Cell Press
336 7 _ |a article
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500 _ _ |a (CC BY-NC-ND)
520 _ _ |a Although the neurogenesis-enhancing effects of exercise have been extensively studied, the molecular mechanisms underlying this response remain unclear. Here, we propose that this is mediated by the exercise-induced systemic release of the antioxidant selenium transport protein, selenoprotein P (SEPP1). Using knockout mouse models, we confirmed that SEPP1 and its receptor low-density lipoprotein receptor-related protein 8 (LRP8) are required for the exercise-induced increase in adult hippocampal neurogenesis. In vivo selenium infusion increased hippocampal neural precursor cell (NPC) proliferation and adult neurogenesis. Mimicking the effect of exercise through dietary selenium supplementation restored neurogenesis and reversed the cognitive decline associated with aging and hippocampal injury, suggesting potential therapeutic relevance. These results provide a molecular mechanism linking exercise-induced changes in the systemic environment to the activation of quiescent hippocampal NPCs and their subsequent recruitment into the neurogenic trajectory.
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650 _ 7 |a adult neurogenesis
|2 Other
650 _ 7 |a aging
|2 Other
650 _ 7 |a dentate gyrus
|2 Other
650 _ 7 |a endothelin-1
|2 Other
650 _ 7 |a exercise
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650 _ 7 |a hippocampal lesion
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650 _ 7 |a hippocampus
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650 _ 7 |a neural precursor cell
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650 _ 7 |a neural stem cell
|2 Other
650 _ 7 |a selenium
|2 Other
650 _ 2 |a Aging
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Cell Proliferation
|2 MeSH
650 _ 2 |a Hippocampus
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Neural Stem Cells: metabolism
|2 MeSH
650 _ 2 |a Neurogenesis: physiology
|2 MeSH
650 _ 2 |a Selenium: metabolism
|2 MeSH
650 _ 2 |a Selenium: pharmacology
|2 MeSH
700 1 _ |a Zhuo, Zhan
|b 1
700 1 _ |a Rust, Ruslan
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700 1 _ |a Wasielewska, Joanna M
|0 P:(DE-2719)9000338
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700 1 _ |a Grönnert, Lisa
|0 P:(DE-2719)9000106
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700 1 _ |a Kowal, Susann
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700 1 _ |a Overall, Rupert W
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700 1 _ |a Adusumilli, Vijay S
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700 1 _ |a Blackmore, Daniel G
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700 1 _ |a Southon, Adam
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700 1 _ |a Ganio, Katherine
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700 1 _ |a McDevitt, Christopher A
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700 1 _ |a Rund, Nicole
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700 1 _ |a Brici, David
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700 1 _ |a Mudiyan, Imesh Aththanayake
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700 1 _ |a Sykes, Alexander M
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700 1 _ |a Rünker, Annette E
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700 1 _ |a Zocher, Sara
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700 1 _ |a Ayton, Scott
|b 18
700 1 _ |a Bush, Ashley I
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700 1 _ |a Bartlett, Perry F
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700 1 _ |a Hou, Sheng-Tao
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700 1 _ |a Kempermann, Gerd
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700 1 _ |a Walker, Tara L
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773 _ _ |a 10.1016/j.cmet.2022.01.005
|g Vol. 34, no. 3, p. 408 - 423.e8
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