%0 Journal Article
%A Frank, Anika
%A Bendig, Jonas
%A Schniewind, Inaki
%A Polanski, Witold H
%A Sobottka, Stephan B
%A Reichmann, Heinz
%A Akgün, Katja
%A Ziemssen, Tjalf
%A Klingelhoefer, Lisa
%A Falkenburger, Björn H
%T Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not.
%J Scientific reports
%V 12
%N 1
%@ 2045-2322
%C [London]
%I Macmillan Publishers Limited, part of Springer Nature
%M DZNE-2022-00053
%P 1446
%D 2022
%X Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson's disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not.
%K Aged
%K Deep Brain Stimulation: adverse effects
%K Deep Brain Stimulation: methods
%K Female
%K Humans
%K Longitudinal Studies
%K Male
%K Middle Aged
%K Neurofilament Proteins: blood
%K Neurons: pathology
%K Neurosurgical Procedures: adverse effects
%K Parkinson Disease: therapy
%K Subthalamic Nucleus: cytology
%K Subthalamic Nucleus: pathology
%K Subthalamic Nucleus: surgery
%K Neurofilament Proteins (NLM Chemicals)
%K neurofilament protein L (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35087088
%2 pmc:PMC8795190
%R 10.1038/s41598-022-05117-x
%U https://pub.dzne.de/record/163273