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000163273 037__ $$aDZNE-2022-00053
000163273 041__ $$aEnglish
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000163273 1001_ $$0P:(DE-2719)9001473$$aFrank, Anika$$b0$$eFirst author$$udzne
000163273 245__ $$aSerum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not.
000163273 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2022
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000163273 520__ $$aDeep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson's disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not.
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000163273 650_7 $$2NLM Chemicals$$aNeurofilament Proteins
000163273 650_7 $$2NLM Chemicals$$aneurofilament protein L
000163273 650_2 $$2MeSH$$aAged
000163273 650_2 $$2MeSH$$aDeep Brain Stimulation: adverse effects
000163273 650_2 $$2MeSH$$aDeep Brain Stimulation: methods
000163273 650_2 $$2MeSH$$aFemale
000163273 650_2 $$2MeSH$$aHumans
000163273 650_2 $$2MeSH$$aLongitudinal Studies
000163273 650_2 $$2MeSH$$aMale
000163273 650_2 $$2MeSH$$aMiddle Aged
000163273 650_2 $$2MeSH$$aNeurofilament Proteins: blood
000163273 650_2 $$2MeSH$$aNeurons: pathology
000163273 650_2 $$2MeSH$$aNeurosurgical Procedures: adverse effects
000163273 650_2 $$2MeSH$$aParkinson Disease: therapy
000163273 650_2 $$2MeSH$$aSubthalamic Nucleus: cytology
000163273 650_2 $$2MeSH$$aSubthalamic Nucleus: pathology
000163273 650_2 $$2MeSH$$aSubthalamic Nucleus: surgery
000163273 7001_ $$aBendig, Jonas$$b1
000163273 7001_ $$0P:(DE-2719)9000748$$aSchniewind, Inaki$$b2$$udzne
000163273 7001_ $$aPolanski, Witold H$$b3
000163273 7001_ $$aSobottka, Stephan B$$b4
000163273 7001_ $$aReichmann, Heinz$$b5
000163273 7001_ $$aAkgün, Katja$$b6
000163273 7001_ $$aZiemssen, Tjalf$$b7
000163273 7001_ $$aKlingelhoefer, Lisa$$b8
000163273 7001_ $$0P:(DE-2719)2814178$$aFalkenburger, Björn H$$b9$$eLast author$$udzne
000163273 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-022-05117-x$$gVol. 12, no. 1, p. 1446$$n1$$p1446$$tScientific reports$$v12$$x2045-2322$$y2022
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