TY  - JOUR
AU  - Frank, Anika
AU  - Bendig, Jonas
AU  - Schniewind, Inaki
AU  - Polanski, Witold H
AU  - Sobottka, Stephan B
AU  - Reichmann, Heinz
AU  - Akgün, Katja
AU  - Ziemssen, Tjalf
AU  - Klingelhoefer, Lisa
AU  - Falkenburger, Björn H
TI  - Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not.
JO  - Scientific reports
VL  - 12
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DZNE-2022-00053
SP  - 1446
PY  - 2022
AB  - Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson's disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not.
KW  - Aged
KW  - Deep Brain Stimulation: adverse effects
KW  - Deep Brain Stimulation: methods
KW  - Female
KW  - Humans
KW  - Longitudinal Studies
KW  - Male
KW  - Middle Aged
KW  - Neurofilament Proteins: blood
KW  - Neurons: pathology
KW  - Neurosurgical Procedures: adverse effects
KW  - Parkinson Disease: therapy
KW  - Subthalamic Nucleus: cytology
KW  - Subthalamic Nucleus: pathology
KW  - Subthalamic Nucleus: surgery
KW  - Neurofilament Proteins (NLM Chemicals)
KW  - neurofilament protein L (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:35087088
C2  - pmc:PMC8795190
DO  - DOI:10.1038/s41598-022-05117-x
UR  - https://pub.dzne.de/record/163273
ER  -