% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Frank:163273,
      author       = {Frank, Anika and Bendig, Jonas and Schniewind, Inaki and
                      Polanski, Witold H and Sobottka, Stephan B and Reichmann,
                      Heinz and Akgün, Katja and Ziemssen, Tjalf and
                      Klingelhoefer, Lisa and Falkenburger, Björn H},
      title        = {{S}erum neurofilament indicates that {DBS} surgery can
                      cause neuronal damage whereas stimulation itself does not.},
      journal      = {Scientific reports},
      volume       = {12},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2022-00053},
      pages        = {1446},
      year         = {2022},
      abstract     = {Deep brain stimulation (DBS) is a potent symptomatic
                      therapy for Parkinson's disease, but it is debated whether
                      it causes or prevents neurodegeneration. We used serum
                      neurofilament light chain (NFL) as a reporter for neuronal
                      damage and found no difference between 92 patients with
                      chronic STN-DBS and 57 patients on best medical treatment.
                      Serum NFL transiently increased after DBS surgery whereas
                      the initiation of STN stimulation did not affect NFL levels,
                      suggesting that DBS surgery can be associated with neuronal
                      damage whereas stimulation itself is not.},
      keywords     = {Aged / Deep Brain Stimulation: adverse effects / Deep Brain
                      Stimulation: methods / Female / Humans / Longitudinal
                      Studies / Male / Middle Aged / Neurofilament Proteins: blood
                      / Neurons: pathology / Neurosurgical Procedures: adverse
                      effects / Parkinson Disease: therapy / Subthalamic Nucleus:
                      cytology / Subthalamic Nucleus: pathology / Subthalamic
                      Nucleus: surgery / Neurofilament Proteins (NLM Chemicals) /
                      neurofilament protein L (NLM Chemicals)},
      cin          = {Clinical Study Team Dresden ; AG Falkenburger / Dresden
                      common},
      ddc          = {600},
      cid          = {I:(DE-2719)1710012 / I:(DE-2719)6000013},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35087088},
      pmc          = {pmc:PMC8795190},
      doi          = {10.1038/s41598-022-05117-x},
      url          = {https://pub.dzne.de/record/163273},
}