Home > Publications Database > Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not. > print

001     163273
005     20230915090515.0
024 7 _ |a 10.1038/s41598-022-05117-x
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100 1 _ |a Frank, Anika
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245 _ _ |a Serum neurofilament indicates that DBS surgery can cause neuronal damage whereas stimulation itself does not.
260 _ _ |a [London]
|c 2022
|b Macmillan Publishers Limited, part of Springer Nature
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520 _ _ |a Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson's disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and found no difference between 92 patients with chronic STN-DBS and 57 patients on best medical treatment. Serum NFL transiently increased after DBS surgery whereas the initiation of STN stimulation did not affect NFL levels, suggesting that DBS surgery can be associated with neuronal damage whereas stimulation itself is not.
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650 _ 7 |a Neurofilament Proteins
|2 NLM Chemicals
650 _ 7 |a neurofilament protein L
|2 NLM Chemicals
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Deep Brain Stimulation: adverse effects
|2 MeSH
650 _ 2 |a Deep Brain Stimulation: methods
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Longitudinal Studies
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Neurofilament Proteins: blood
|2 MeSH
650 _ 2 |a Neurons: pathology
|2 MeSH
650 _ 2 |a Neurosurgical Procedures: adverse effects
|2 MeSH
650 _ 2 |a Parkinson Disease: therapy
|2 MeSH
650 _ 2 |a Subthalamic Nucleus: cytology
|2 MeSH
650 _ 2 |a Subthalamic Nucleus: pathology
|2 MeSH
650 _ 2 |a Subthalamic Nucleus: surgery
|2 MeSH
700 1 _ |a Bendig, Jonas
|b 1
700 1 _ |a Schniewind, Inaki
|0 P:(DE-2719)9000748
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700 1 _ |a Polanski, Witold H
|b 3
700 1 _ |a Sobottka, Stephan B
|b 4
700 1 _ |a Reichmann, Heinz
|b 5
700 1 _ |a Akgün, Katja
|b 6
700 1 _ |a Ziemssen, Tjalf
|b 7
700 1 _ |a Klingelhoefer, Lisa
|b 8
700 1 _ |a Falkenburger, Björn H
|0 P:(DE-2719)2814178
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773 _ _ |a 10.1038/s41598-022-05117-x
|g Vol. 12, no. 1, p. 1446
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|t Scientific reports
|v 12
|y 2022
|x 2045-2322
856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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914 1 _ |y 2022
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