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000163322 0247_ $$2doi$$a10.1016/j.cell.2021.11.033
000163322 0247_ $$2pmid$$apmid:34914922
000163322 0247_ $$2pmc$$apmc:PMC8626230
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000163322 0247_ $$2ISSN$$a1097-4172
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000163322 037__ $$aDZNE-2022-00102
000163322 041__ $$aEnglish
000163322 082__ $$a610
000163322 1001_ $$aWendisch, Daniel$$b0
000163322 245__ $$aSARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
000163322 260__ $$aNew York, NY$$bElsevier$$c2021
000163322 3367_ $$2DRIVER$$aarticle
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000163322 520__ $$aCOVID-19-induced 'acute respiratory distress syndrome' (ARDS) is associated with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury remains incompletely understood. Here, we analyze pulmonary immune responses and lung pathology in two cohorts of patients with COVID-19 ARDS using functional single-cell genomics, immunohistology, and electron microscopy. We describe an accumulation of CD163-expressing monocyte-derived macrophages that acquired a profibrotic transcriptional phenotype during COVID-19 ARDS. Gene set enrichment and computational data integration revealed a significant similarity between COVID-19-associated macrophages and profibrotic macrophage populations identified in idiopathic pulmonary fibrosis. COVID-19 ARDS was associated with clinical, radiographic, histopathological, and ultrastructural hallmarks of pulmonary fibrosis. Exposure of human monocytes to SARS-CoV-2, but not influenza A virus or viral RNA analogs, was sufficient to induce a similar profibrotic phenotype in vitro. In conclusion, we demonstrate that SARS-CoV-2 triggers profibrotic macrophage responses and pronounced fibroproliferative ARDS.
000163322 536__ $$0G:(DE-HGF)POF4-354$$a354 - Disease Prevention and Healthy Aging (POF4-354)$$cPOF4-354$$fPOF IV$$x0
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000163322 650_7 $$2Other$$aARDS
000163322 650_7 $$2Other$$aCOVID-19
000163322 650_7 $$2Other$$aIPF
000163322 650_7 $$2Other$$aSARS-CoV-2
000163322 650_7 $$2Other$$afibrosis
000163322 650_7 $$2Other$$alung
000163322 650_7 $$2Other$$amacrophages
000163322 650_7 $$2Other$$amonocytes
000163322 650_7 $$2Other$$aproteomics
000163322 650_7 $$2Other$$apulmonary fibrosis
000163322 650_7 $$2Other$$asingle-cell transcriptomics
000163322 650_7 $$2NLM Chemicals$$aAntigens, CD
000163322 650_7 $$2NLM Chemicals$$aAntigens, Differentiation, Myelomonocytic
000163322 650_7 $$2NLM Chemicals$$aCD163 antigen
000163322 650_7 $$2NLM Chemicals$$aProteome
000163322 650_7 $$2NLM Chemicals$$aReceptors, Cell Surface
000163322 650_2 $$2MeSH$$aAntigens, CD: metabolism
000163322 650_2 $$2MeSH$$aAntigens, Differentiation, Myelomonocytic: metabolism
000163322 650_2 $$2MeSH$$aCOVID-19: diagnostic imaging
000163322 650_2 $$2MeSH$$aCOVID-19: pathology
000163322 650_2 $$2MeSH$$aCOVID-19: virology
000163322 650_2 $$2MeSH$$aCell Communication
000163322 650_2 $$2MeSH$$aCohort Studies
000163322 650_2 $$2MeSH$$aFibroblasts: pathology
000163322 650_2 $$2MeSH$$aGene Expression Regulation
000163322 650_2 $$2MeSH$$aHumans
000163322 650_2 $$2MeSH$$aIdiopathic Pulmonary Fibrosis: diagnostic imaging
000163322 650_2 $$2MeSH$$aIdiopathic Pulmonary Fibrosis: genetics
000163322 650_2 $$2MeSH$$aIdiopathic Pulmonary Fibrosis: pathology
000163322 650_2 $$2MeSH$$aIdiopathic Pulmonary Fibrosis: virology
000163322 650_2 $$2MeSH$$aMacrophages: pathology
000163322 650_2 $$2MeSH$$aMacrophages: virology
000163322 650_2 $$2MeSH$$aMesenchymal Stem Cells: pathology
000163322 650_2 $$2MeSH$$aPhenotype
000163322 650_2 $$2MeSH$$aProteome: metabolism
000163322 650_2 $$2MeSH$$aReceptors, Cell Surface: metabolism
000163322 650_2 $$2MeSH$$aRespiratory Distress Syndrome: diagnostic imaging
000163322 650_2 $$2MeSH$$aRespiratory Distress Syndrome: pathology
000163322 650_2 $$2MeSH$$aRespiratory Distress Syndrome: virology
000163322 650_2 $$2MeSH$$aSARS-CoV-2: physiology
000163322 650_2 $$2MeSH$$aTomography, X-Ray Computed
000163322 650_2 $$2MeSH$$aTranscription, Genetic
000163322 7001_ $$aDietrich, Oliver$$b1
000163322 7001_ $$aMari, Tommaso$$b2
000163322 7001_ $$avon Stillfried, Saskia$$b3
000163322 7001_ $$aIbarra, Ignacio L$$b4
000163322 7001_ $$aMittermaier, Mirja$$b5
000163322 7001_ $$aMache, Christin$$b6
000163322 7001_ $$aChua, Robert Lorenz$$b7
000163322 7001_ $$0P:(DE-2719)9000620$$aKnoll, Rainer$$b8$$udzne
000163322 7001_ $$aTimm, Sara$$b9
000163322 7001_ $$aBrumhard, Sophia$$b10
000163322 7001_ $$aKrammer, Tobias$$b11
000163322 7001_ $$aZauber, Henrik$$b12
000163322 7001_ $$aHiller, Anna Luisa$$b13
000163322 7001_ $$aPascual-Reguant, Anna$$b14
000163322 7001_ $$aMothes, Ronja$$b15
000163322 7001_ $$aBülow, Roman David$$b16
000163322 7001_ $$aSchulze, Jessica$$b17
000163322 7001_ $$aLeipold, Alexander M$$b18
000163322 7001_ $$aDjudjaj, Sonja$$b19
000163322 7001_ $$aErhard, Florian$$b20
000163322 7001_ $$aGeffers, Robert$$b21
000163322 7001_ $$aPott, Fabian$$b22
000163322 7001_ $$aKazmierski, Julia$$b23
000163322 7001_ $$aRadke, Josefine$$b24
000163322 7001_ $$aPergantis, Panagiotis$$b25
000163322 7001_ $$0P:(DE-2719)9000836$$aBaßler, Kevin$$b26$$udzne
000163322 7001_ $$aConrad, Claudia$$b27
000163322 7001_ $$0P:(DE-2719)2812913$$aAschenbrenner, Anna C$$b28$$udzne
000163322 7001_ $$aSawitzki, Birgit$$b29
000163322 7001_ $$aLandthaler, Markus$$b30
000163322 7001_ $$aWyler, Emanuel$$b31
000163322 7001_ $$aHorst, David$$b32
000163322 7001_ $$aInitiative, Deutsche COVID-19 OMICS$$b33$$eCollaboration Author
000163322 7001_ $$aHippenstiel, Stefan$$b34
000163322 7001_ $$aHocke, Andreas$$b35
000163322 7001_ $$0P:(DE-2719)2812386$$aHeppner, Frank L$$b36$$udzne
000163322 7001_ $$aUhrig, Alexander$$b37
000163322 7001_ $$aGarcia, Carmen$$b38
000163322 7001_ $$aMachleidt, Felix$$b39
000163322 7001_ $$aHerold, Susanne$$b40
000163322 7001_ $$aElezkurtaj, Sefer$$b41
000163322 7001_ $$aThibeault, Charlotte$$b42
000163322 7001_ $$aWitzenrath, Martin$$b43
000163322 7001_ $$aCochain, Clément$$b44
000163322 7001_ $$aSuttorp, Norbert$$b45
000163322 7001_ $$aDrosten, Christian$$b46
000163322 7001_ $$aGoffinet, Christine$$b47
000163322 7001_ $$aKurth, Florian$$b48
000163322 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b49$$udzne
000163322 7001_ $$aRadbruch, Helena$$b50
000163322 7001_ $$aOchs, Matthias$$b51
000163322 7001_ $$aEils, Roland$$b52
000163322 7001_ $$aMüller-Redetzky, Holger$$b53
000163322 7001_ $$aHauser, Anja E$$b54
000163322 7001_ $$aLuecken, Malte D$$b55
000163322 7001_ $$aTheis, Fabian J$$b56
000163322 7001_ $$aConrad, Christian$$b57
000163322 7001_ $$aWolff, Thorsten$$b58
000163322 7001_ $$aBoor, Peter$$b59
000163322 7001_ $$aSelbach, Matthias$$b60
000163322 7001_ $$aSaliba, Antoine-Emmanuel$$b61
000163322 7001_ $$aSander, Leif Erik$$b62
000163322 773__ $$0PERI:(DE-600)2001951-8$$a10.1016/j.cell.2021.11.033$$gVol. 184, no. 26, p. 6243 - 6261.e27$$n26$$p6243 - 6261.e27$$tCell$$v184$$x0092-8674$$y2021
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