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@ARTICLE{Dehestani:163360,
      author       = {Dehestani, Mohammad and Liu, Hui and Gasser, Thomas},
      title        = {{P}olygenic {R}isk {S}cores {C}ontribute to {P}ersonalized
                      {M}edicine of {P}arkinson's {D}isease.},
      journal      = {Journal of Personalized Medicine},
      volume       = {11},
      number       = {10},
      issn         = {2075-4426},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DZNE-2022-00123},
      pages        = {1030},
      year         = {2021},
      note         = {CC BY},
      abstract     = {Parkinson's disease (PD) is the second most common
                      neurodegenerative disorder characterized by the loss of
                      dopaminergic neurons. The vast majority of PD patients
                      develop the disease sporadically and it is assumed that the
                      cause lies in polygenic and environmental components. The
                      overall polygenic risk is the result of a large number of
                      common low-risk variants discovered by large genome-wide
                      association studies (GWAS). Polygenic risk scores (PRS),
                      generated by compiling genome-wide significant variants, are
                      a useful prognostic tool that quantifies the cumulative
                      effect of genetic risk in a patient and in this way helps to
                      identify high-risk patients. Although there are limitations
                      to the construction and application of PRS, such as
                      considerations of limited genetic underpinning of diseases
                      explained by SNPs and generalizability of PRS to other
                      populations, this personalized risk prediction could make a
                      promising contribution to stratified medicine and tailored
                      therapeutic interventions in the future.},
      subtyp        = {Review Article},
      keywords     = {Parkinson’s disease (Other) / personalized medicine
                      (Other) / polygenic risk scores (Other)},
      cin          = {AG Gasser / Tübingen common},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000 / I:(DE-2719)6000018},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34683174},
      pmc          = {pmc:PMC8539098},
      doi          = {10.3390/jpm11101030},
      url          = {https://pub.dzne.de/record/163360},
}