TY  - JOUR
AU  - Kilo, Lukas
AU  - Stürner, Tomke
AU  - Tavosanis, Gaia
AU  - Ziegler, Anna B
TI  - Drosophila Dendritic Arborisation Neurons: Fantastic Actin Dynamics and Where to Find Them.
JO  - Cells
VL  - 10
IS  - 10
SN  - 2073-4409
CY  - Basel
PB  - MDPI
M1  - DZNE-2022-00129
SP  - 2777
PY  - 2021
N1  - (CC BY)
AB  - Neuronal dendrites receive, integrate, and process numerous inputs and therefore serve as the neuron's 'antennae'. Dendrites display extreme morphological diversity across different neuronal classes to match the neuron's specific functional requirements. Understanding how this structural diversity is specified is therefore important for shedding light on information processing in the healthy and diseased nervous system. Popular models for in vivo studies of dendrite differentiation are the four classes of dendritic arborization (c1da-c4da) neurons of Drosophila larvae with their class-specific dendritic morphologies. Using da neurons, a combination of live-cell imaging and computational approaches have delivered information on the distinct phases and the time course of dendrite development from embryonic stages to the fully developed dendritic tree. With these data, we can start approaching the basic logic behind differential dendrite development. A major role in the definition of neuron-type specific morphologies is played by dynamic actin-rich processes and the regulation of their properties. This review presents the differences in the growth programs leading to morphologically different dendritic trees, with a focus on the key role of actin modulatory proteins. In addition, we summarize requirements and technological progress towards the visualization and manipulation of such actin regulators in vivo.
KW  - Actins: metabolism
KW  - Animals
KW  - Cell Differentiation
KW  - Dendrites: metabolism
KW  - Drosophila: metabolism
KW  - actin (Other)
KW  - dendrite arborization (da) neurons (Other)
KW  - neuronal dendrites (Other)
KW  - time-lapse imaging (Other)
KW  - Actins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:34685757
C2  - pmc:PMC8534399
DO  - DOI:10.3390/cells10102777
UR  - https://pub.dzne.de/record/163366
ER  -