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000163375 037__ $$aDZNE-2022-00138
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000163375 1001_ $$aMiglis, Mitchell G$$b0
000163375 245__ $$aBiomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder
000163375 260__ $$aLondon$$bLancet Publ. Group$$c2021
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000163375 520__ $$aPatients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving α-synuclein pathology, such as Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal α-synuclein deposition occurs early in the neurodegenerative process across the central and peripheral nervous systems and might precede the appearance of motor symptoms and cognitive decline by several decades. These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest α-synucleinopathies. In addition, biomarkers of disease progression will be essential to monitor treatment response once disease-modifying therapies become available, and biomarkers of disease subtype will be essential to enable prediction of which subtype of α-synucleinopathy patients with isolated RBD might develop.
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000163375 650_2 $$2MeSH$$aBiomarkers
000163375 650_2 $$2MeSH$$aDisease Progression
000163375 650_2 $$2MeSH$$aHumans
000163375 650_2 $$2MeSH$$aPrognosis
000163375 650_2 $$2MeSH$$aREM Sleep Behavior Disorder: complications
000163375 650_2 $$2MeSH$$aREM Sleep Behavior Disorder: diagnosis
000163375 650_2 $$2MeSH$$aSynucleinopathies: diagnosis
000163375 650_2 $$2MeSH$$aSynucleinopathies: etiology
000163375 650_2 $$2MeSH$$aalpha-Synuclein
000163375 7001_ $$aAdler, Charles H$$b1
000163375 7001_ $$aAntelmi, Elena$$b2
000163375 7001_ $$aArnaldi, Dario$$b3
000163375 7001_ $$aBaldelli, Luca$$b4
000163375 7001_ $$aBoeve, Bradley F$$b5
000163375 7001_ $$aCesari, Matteo$$b6
000163375 7001_ $$aDall'Antonia, Irene$$b7
000163375 7001_ $$aDiederich, Nico J$$b8
000163375 7001_ $$aDoppler, Kathrin$$b9
000163375 7001_ $$aDušek, Petr$$b10
000163375 7001_ $$aFerri, Raffaele$$b11
000163375 7001_ $$aGagnon, Jean-François$$b12
000163375 7001_ $$aGan-Or, Ziv$$b13
000163375 7001_ $$0P:(DE-2719)2814194$$aHermann, Wiebke$$b14$$udzne
000163375 7001_ $$aHögl, Birgit$$b15
000163375 7001_ $$aHu, Michele T$$b16
000163375 7001_ $$aIranzo, Alex$$b17
000163375 7001_ $$aJanzen, Annette$$b18
000163375 7001_ $$aKuzkina, Anastasia$$b19
000163375 7001_ $$aLee, Jee-Young$$b20
000163375 7001_ $$aLeenders, Klaus L$$b21
000163375 7001_ $$aLewis, Simon J G$$b22
000163375 7001_ $$aLiguori, Claudio$$b23
000163375 7001_ $$aLiu, Jun$$b24
000163375 7001_ $$aLo, Christine$$b25
000163375 7001_ $$aEhgoetz Martens, Kaylena A$$b26
000163375 7001_ $$aNepozitek, Jiri$$b27
000163375 7001_ $$aPlazzi, Giuseppe$$b28
000163375 7001_ $$aProvini, Federica$$b29
000163375 7001_ $$aPuligheddu, Monica$$b30
000163375 7001_ $$aRolinski, Michal$$b31
000163375 7001_ $$aRusz, Jan$$b32
000163375 7001_ $$aStefani, Ambra$$b33
000163375 7001_ $$aSummers, Rebekah L S$$b34
000163375 7001_ $$aYoo, Dallah$$b35
000163375 7001_ $$aZitser, Jennifer$$b36
000163375 7001_ $$0P:(DE-2719)9000908$$aOertel, Wolfgang H$$b37$$udzne
000163375 773__ $$0PERI:(DE-600)2079704-7$$a10.1016/S1474-4422(21)00176-9$$gVol. 20, no. 8, p. 671 - 684$$n8$$p671 - 684$$tThe lancet <London> / Neurology$$v20$$x1474-4422$$y2021
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