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@ARTICLE{Pignolo:163387,
      author       = {Pignolo, Loris and Tonin, Paolo and Nicotera, Pierluigi and
                      Bagetta, Giacinto and Scuteri, Damiana},
      title        = {{ROBOCOP} ({ROBO}tic {C}are of {P}oststroke {P}ain):
                      {S}tudy {P}rotocol for a {R}andomized {T}rial to {A}ssess
                      {R}obot-{A}ssisted {F}unctional and {M}otor {R}ecovery and
                      {I}mpact on {P}oststroke {P}ain {D}evelopment.},
      journal      = {Frontiers in neurology},
      volume       = {13},
      issn         = {1664-2295},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2022-00149},
      pages        = {813282},
      year         = {2022},
      abstract     = {Stroke is one of the most frequent causes of death and
                      disability worldwide. It is accompanied by the impaired
                      motor function of the upper extremities in over $69\%$ of
                      patients up to hemiplegia in the following 5 years in $56\%$
                      of cases. This condition often is characterized by chronic
                      poststroke pain, difficult to manage, further worsening
                      quality of life. Poststroke pain occurs within 3-6 months.
                      Robot-assisted neurorehabilitation using the Automatic
                      Recovery Arm Motility Integrated System (ARAMIS) has proven
                      efficacy in motor function recovery exploiting the movements
                      and the strength of the unaffected arm. The rationale of the
                      ROBOCOP (ROBOtic Care of Poststroke pain) randomized trial
                      is the assessment of the impact of robot-assisted functional
                      and motor recovery on the prevention of poststroke pain.A
                      total of 118 patients with hemiplegic arms due to stroke
                      will be enrolled and randomly allocated with a 1:1 ratio to
                      ARAMIS or conventional neurorehabilitation group. After a
                      baseline screening at hospital discharge, ARAMIS or
                      conventional rehabilitation will be performed for 8 weeks.
                      The primary endpoint is the prevention of the development of
                      poststroke pain and the secondary endpoints are prevention
                      of spasticity and efficacy in clinical motor rehabilitation.
                      The primary outcome measures consist in the visual analog
                      scale and the doleur neuropatique 4 and the secondary
                      outcome measures include: the Modified Ashworth Scale, the
                      Resistance to Passive movement Scale; the Upper Extremity
                      Subscale of the Fugl-Meyer Motor Assessment; the Action
                      Research Arm Test; the Barthel Index for activities of daily
                      living; and the magnetic resonance imaging (MRI)
                      recovery-related parameters. After baseline, both primary
                      and secondary outcome measures will be performed in the
                      following time points: 1 month after stroke (t 1, half of
                      the rehabilitation); 2 months after stroke (t 2, after
                      rehabilitation); and 3 months (t 3) and 6 months (t 4) after
                      stroke, critical for poststroke pain development.This is the
                      first clinical trial investigating the efficacy of
                      robot-assisted neurorehabilitation using ARAMIS on
                      poststroke pain prevention. This study could remarkably
                      improve the quality of life of stroke survivors.},
      keywords     = {ARAMIS (Other) / motor rehabilitation (Other) / post-stroke
                      pain (Other) / robot-assisted neurorehabilitation (Other) /
                      stroke recovery (Other)},
      cin          = {AG Bano / Scientific board},
      ddc          = {610},
      cid          = {I:(DE-2719)1013003 / I:(DE-2719)1030000},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35250820},
      pmc          = {pmc:PMC8894665},
      doi          = {10.3389/fneur.2022.813282},
      url          = {https://pub.dzne.de/record/163387},
}