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@ARTICLE{Strauch:163420,
      author       = {Strauch, Christina and Hoang, Thu-Huong and Angenstein,
                      Frank and Manahan-Vaughan, Denise},
      title        = {{O}lfactory {I}nformation {S}torage {E}ngages {S}ubcortical
                      and {C}ortical {B}rain {R}egions {T}hat {S}upport {V}alence
                      {D}etermination.},
      journal      = {Cerebral cortex},
      volume       = {32},
      number       = {4},
      issn         = {1460-2199},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2022-00180},
      pages        = {689 - 708},
      year         = {2022},
      note         = {(CC BY-NC)},
      abstract     = {The olfactory bulb (OB) delivers sensory information to the
                      piriform cortex (PC) and other components of the olfactory
                      system. OB-PC synapses have been reported to express
                      short-lasting forms of synaptic plasticity, whereas
                      long-term potentiation (LTP) of the anterior PC (aPC) occurs
                      predominantly by activating inputs from the prefrontal
                      cortex. This suggests that brain regions outside the
                      olfactory system may contribute to olfactory information
                      processing and storage. Here, we compared functional
                      magnetic resonance imaging BOLD responses triggered during
                      20 or 100 Hz stimulation of the OB. We detected BOLD signal
                      increases in the anterior olfactory nucleus (AON), PC and
                      entorhinal cortex, nucleus accumbens, dorsal striatum,
                      ventral diagonal band of Broca, prelimbic-infralimbic cortex
                      (PrL-IL), dorsal medial prefrontal cortex, and basolateral
                      amygdala. Significantly stronger BOLD responses occurred in
                      the PrL-IL, PC, and AON during 100 Hz compared with 20 Hz OB
                      stimulation. LTP in the aPC was concomitantly induced by 100
                      Hz stimulation. Furthermore, 100 Hz stimulation triggered
                      significant nuclear immediate early gene expression in aPC,
                      AON, and PrL-IL. The involvement of the PrL-IL in this
                      process is consistent with its putative involvement in
                      modulating behavioral responses to odor experience.
                      Furthermore, these results indicate that OB-mediated
                      information storage by the aPC is embedded in a connectome
                      that supports valence evaluation.},
      keywords     = {Information Storage and Retrieval / Neuronal Plasticity:
                      physiology / Olfactory Bulb: physiology / Piriform Cortex:
                      physiology / Smell: physiology / fMRI (Other) / immediate
                      early gene (Other) / olfactory system (Other) / prelimbic
                      cortex (Other) / synaptic plasticity (Other)},
      cin          = {AG Angenstein},
      ddc          = {610},
      cid          = {I:(DE-2719)1310004},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34379749},
      pmc          = {pmc:PMC8841565},
      doi          = {10.1093/cercor/bhab226},
      url          = {https://pub.dzne.de/record/163420},
}