TY  - JOUR
AU  - Segen, Vladislava
AU  - Ying, Johnson
AU  - Morgan, Erik
AU  - Brandon, Mark
AU  - Wolbers, Thomas
TI  - Path integration in normal aging and Alzheimer's disease.
JO  - Trends in cognitive sciences
VL  - 26
IS  - 2
SN  - 1364-6613
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2022-00188
SP  - 142 - 158
PY  - 2022
AB  - In this review we discuss converging evidence from human and rodent research demonstrating how path integration (PI) is impaired in healthy aging and Alzheimer's disease (AD), and point to the neural mechanisms that underlie these deficits. Importantly, we highlight that (i) the grid cell network in the entorhinal cortex is crucial for PI in both humans and rodents, (ii) PI deficits are present in healthy aging and are significantly more pronounced in patients with early-stage AD, (iii) compromised entorhinal grid cell computations in healthy older adults and in young adults at risk of AD are linked to PI deficits, and (iv) PI and grid cell deficits may serve as sensitive markers for pathological decline in early AD.
KW  - Aged
KW  - Aging
KW  - Alzheimer Disease
KW  - Entorhinal Cortex: pathology
KW  - Humans
KW  - Alzheimer’s disease (Other)
KW  - aging (Other)
KW  - entorhinal cortex (Other)
KW  - grid cells (Other)
KW  - navigation (Other)
KW  - path integration (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34872838
DO  - DOI:10.1016/j.tics.2021.11.001
UR  - https://pub.dzne.de/record/163428
ER  -