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@ARTICLE{Segen:163428,
      author       = {Segen, Vladislava and Ying, Johnson and Morgan, Erik and
                      Brandon, Mark and Wolbers, Thomas},
      title        = {{P}ath integration in normal aging and {A}lzheimer's
                      disease.},
      journal      = {Trends in cognitive sciences},
      volume       = {26},
      number       = {2},
      issn         = {1364-6613},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2022-00188},
      pages        = {142 - 158},
      year         = {2022},
      abstract     = {In this review we discuss converging evidence from human
                      and rodent research demonstrating how path integration (PI)
                      is impaired in healthy aging and Alzheimer's disease (AD),
                      and point to the neural mechanisms that underlie these
                      deficits. Importantly, we highlight that (i) the grid cell
                      network in the entorhinal cortex is crucial for PI in both
                      humans and rodents, (ii) PI deficits are present in healthy
                      aging and are significantly more pronounced in patients with
                      early-stage AD, (iii) compromised entorhinal grid cell
                      computations in healthy older adults and in young adults at
                      risk of AD are linked to PI deficits, and (iv) PI and grid
                      cell deficits may serve as sensitive markers for
                      pathological decline in early AD.},
      subtyp        = {Review Article},
      keywords     = {Aged / Aging / Alzheimer Disease / Entorhinal Cortex:
                      pathology / Humans / Alzheimer’s disease (Other) / aging
                      (Other) / entorhinal cortex (Other) / grid cells (Other) /
                      navigation (Other) / path integration (Other)},
      cin          = {AG Wolbers},
      ddc          = {150},
      cid          = {I:(DE-2719)1310002},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34872838},
      doi          = {10.1016/j.tics.2021.11.001},
      url          = {https://pub.dzne.de/record/163428},
}