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001     163428
005     20231214131122.0
024 7 _ |a 10.1016/j.tics.2021.11.001
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024 7 _ |a pmid:34872838
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024 7 _ |a 1364-6613
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024 7 _ |a 1879-307X
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037 _ _ |a DZNE-2022-00188
041 _ _ |a English
082 _ _ |a 150
100 1 _ |a Segen, Vladislava
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245 _ _ |a Path integration in normal aging and Alzheimer's disease.
260 _ _ |a Amsterdam [u.a.]
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520 _ _ |a In this review we discuss converging evidence from human and rodent research demonstrating how path integration (PI) is impaired in healthy aging and Alzheimer's disease (AD), and point to the neural mechanisms that underlie these deficits. Importantly, we highlight that (i) the grid cell network in the entorhinal cortex is crucial for PI in both humans and rodents, (ii) PI deficits are present in healthy aging and are significantly more pronounced in patients with early-stage AD, (iii) compromised entorhinal grid cell computations in healthy older adults and in young adults at risk of AD are linked to PI deficits, and (iv) PI and grid cell deficits may serve as sensitive markers for pathological decline in early AD.
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650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a aging
|2 Other
650 _ 7 |a entorhinal cortex
|2 Other
650 _ 7 |a grid cells
|2 Other
650 _ 7 |a navigation
|2 Other
650 _ 7 |a path integration
|2 Other
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aging
|2 MeSH
650 _ 2 |a Alzheimer Disease
|2 MeSH
650 _ 2 |a Entorhinal Cortex: pathology
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
700 1 _ |a Ying, Johnson
|b 1
700 1 _ |a Morgan, Erik
|b 2
700 1 _ |a Brandon, Mark
|b 3
700 1 _ |a Wolbers, Thomas
|0 P:(DE-2719)2810583
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773 _ _ |a 10.1016/j.tics.2021.11.001
|g Vol. 26, no. 2, p. 142 - 158
|0 PERI:(DE-600)2010989-1
|n 2
|p 142 - 158
|t Trends in cognitive sciences
|v 26
|y 2022
|x 1364-6613
856 4 _ |u https://pub.dzne.de/record/163428/files/DZNE-2022-00188_Restricted.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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