%0 Journal Article
%A Hermann, Peter
%A Villar-Piqué, Anna
%A Schmitz, Matthias
%A Schmidt, Christian
%A Varges, Daniela
%A Goebel, Stefan
%A Bunck, Timothy
%A Lindemann, Hanna
%A Bogner, Carla
%A Santana, Isabel
%A Baldeiras, Inês
%A Riggert, Joachim
%A Zerr, Inga
%A Llorens Torres, Francesc Josep
%T Plasma Lipocalin 2 in Alzheimer's disease: potential utility in the differential diagnosis and relationship with other biomarkers.
%J Alzheimer's research & therapy
%V 14
%N 1
%@ 1758-9193
%C London
%I BioMed Central
%M DZNE-2022-00194
%P 9
%D 2022
%X Lipocalin-2 is a glycoprotein that is involved in various physiological and pathophysiological processes. In the brain, it is expressed in response to vascular and other brain injury, as well as in Alzheimer's disease in reactive microglia and astrocytes. Plasma Lipocalin-2 has been proposed as a biomarker for Alzheimer's disease but available data is scarce and inconsistent. Thus, we evaluated plasma Lipocalin-2 in the context of Alzheimer's disease, differential diagnoses, other biomarkers, and clinical data.For this two-center case-control study, we analyzed Lipocalin-2 concentrations in plasma samples from a cohort of n = 407 individuals. The diagnostic groups comprised Alzheimer's disease (n = 74), vascular dementia (n = 28), other important differential diagnoses (n = 221), and healthy controls (n = 84). Main results were validated in an independent cohort with patients with Alzheimer's disease (n = 19), mild cognitive impairment (n = 27), and healthy individuals (n = 28).Plasma Lipocalin-2 was significantly lower in Alzheimer's disease compared to healthy controls (p < 0.001) and all other groups (p < 0.01) except for mixed dementia (vascular and Alzheimer's pathologic changes). Areas under the curve from receiver operation characteristics for the discrimination of Alzheimer's disease and healthy controls were 0.783 (95
%K Alzheimer Disease: blood
%K Alzheimer Disease: cerebrospinal fluid
%K Alzheimer Disease: diagnosis
%K Amyloid beta-Peptides: blood
%K Amyloid beta-Peptides: cerebrospinal fluid
%K Biomarkers: blood
%K Biomarkers: cerebrospinal fluid
%K Case-Control Studies
%K Cognitive Dysfunction: diagnosis
%K Diagnosis, Differential
%K Humans
%K Lipocalin-2: blood
%K tau Proteins
%K Alzheimer’s disease (Other)
%K Biomarker (Other)
%K Dementia (Other)
%K Lipocalin 2 (Other)
%K Neutrophil gelatinase-associated Lipocalin (Other)
%K Plasma (Other)
%K Amyloid beta-Peptides (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Lipocalin-2 (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35027079
%2 pmc:PMC8759265
%R 10.1186/s13195-021-00955-9
%U https://pub.dzne.de/record/163434