TY  - JOUR
AU  - Kilimann, Ingo
AU  - Wucherer, Diana
AU  - Ittermann, Till
AU  - Völzke, Henry
AU  - Bülow, Robin
AU  - Hoffmann, Wolfgang
AU  - Grabe, Hans Jörgen
AU  - Wittfeld, Katharina
AU  - Teipel, Stefan Johannes
TI  - Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range.
JO  - GeroScience
VL  - 44
IS  - 3
SN  - 2509-2723
CY  - [Cham]
PB  - Springer International Publishing
M1  - DZNE-2022-00212
SP  - 1715-1726
PY  - 2022
N1  - (CC BY)
AB  - Many medications of different indications have a relevant anticholinergic activity. The anticholinergic burden of medication has been shown to have significant effects on the cognition and the risk for cognitive impairment and dementia particularly in older patients. So far, most of the studies used data from geriatric patients and the effect of the anticholinergic burden on brain structures is still unexplored. Our study aimed to analyze possible associations of hippocampus and cholinergic basal forebrain volumes as vulnerable brain structures for the development of dementia and the anticholinergic burden in a population-based cohort of non-demented participants spanning the adult age range from 21 to 80 years. We analyzed associations between medication-related anticholinergic burden and structural MRI volumes from participants (n = 3087, 52.2
KW  - Aged
KW  - Aged, 80 and over
KW  - Cholinergic Agents: therapeutic use
KW  - Cholinergic Antagonists: adverse effects
KW  - Cognitive Dysfunction: chemically induced
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: drug therapy
KW  - Dementia
KW  - Female
KW  - Hippocampus: diagnostic imaging
KW  - Humans
KW  - Male
KW  - Alzheimer’s disease (Other)
KW  - Cognitive impairment (Other)
KW  - Hippocampus (Other)
KW  - Medication (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC9213601
C6  - pmid:34940948
DO  - DOI:10.1007/s11357-021-00497-w
UR  - https://pub.dzne.de/record/163452
ER  -