TY  - JOUR
AU  - Sammons, Rosanna P
AU  - Tzilivaki, Alexandra
AU  - Schmitz, Dietmar
TI  - Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity.
JO  - Cerebral cortex
VL  - 32
IS  - 1
SN  - 1460-2199
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2022-00223
SP  - 76-92
PY  - 2021
N1  - (CC BY-NC)
AB  - The parasubiculum (PaS) is located within the parahippocampal region, where it is thought to be involved in the processing of spatial navigational information. It contains a number of functionally specialized neuron types including grid cells, head direction cells, and border cells; and provides input into layer 2 of the medial entorhinal cortex where grid cells are abundantly located. The local circuitry within the PaS remains so far undefined but may provide clues as to the emergence of spatially tuned firing properties of neurons in this region. We used simultaneous patch-clamp recordings to determine the connectivity rates between the 3 major groups of neurons found in the PaS. We find high rates of interconnectivity between the pyramidal class and interneurons, as well as features of pyramid-to-pyramid interactions indicative of a nonrandom network. The microcircuit that we uncover shares both similarities and divergences to those from other parahippocampal regions also involved in spatial navigation.
KW  - Action Potentials: physiology
KW  - Entorhinal Cortex: physiology
KW  - Interneurons: physiology
KW  - Neurons: physiology
KW  - Parahippocampal Gyrus: physiology
KW  - Spatial Navigation: physiology
KW  - PaS (Other)
KW  - circuits (Other)
KW  - excitatory (Other)
KW  - inhibitory (Other)
KW  - spatial navigation (Other)
KW  - synaptic connectivity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34289029
C2  - pmc:PMC8634576
DO  - DOI:10.1093/cercor/bhab195
UR  - https://pub.dzne.de/record/163463
ER  -