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@ARTICLE{Sammons:163463,
author = {Sammons, Rosanna P and Tzilivaki, Alexandra and Schmitz,
Dietmar},
title = {{L}ocal {M}icrocircuitry of {P}a{S} {S}hows {D}istinct and
{C}ommon {F}eatures of {E}xcitatory and {I}nhibitory
{C}onnectivity.},
journal = {Cerebral cortex},
volume = {32},
number = {1},
issn = {1460-2199},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {DZNE-2022-00223},
pages = {76-92},
year = {2021},
note = {(CC BY-NC)},
abstract = {The parasubiculum (PaS) is located within the
parahippocampal region, where it is thought to be involved
in the processing of spatial navigational information. It
contains a number of functionally specialized neuron types
including grid cells, head direction cells, and border
cells; and provides input into layer 2 of the medial
entorhinal cortex where grid cells are abundantly located.
The local circuitry within the PaS remains so far undefined
but may provide clues as to the emergence of spatially tuned
firing properties of neurons in this region. We used
simultaneous patch-clamp recordings to determine the
connectivity rates between the 3 major groups of neurons
found in the PaS. We find high rates of interconnectivity
between the pyramidal class and interneurons, as well as
features of pyramid-to-pyramid interactions indicative of a
nonrandom network. The microcircuit that we uncover shares
both similarities and divergences to those from other
parahippocampal regions also involved in spatial
navigation.},
keywords = {Action Potentials: physiology / Entorhinal Cortex:
physiology / Interneurons: physiology / Neurons: physiology
/ Parahippocampal Gyrus: physiology / Spatial Navigation:
physiology / PaS (Other) / circuits (Other) / excitatory
(Other) / inhibitory (Other) / spatial navigation (Other) /
synaptic connectivity (Other)},
cin = {AG Schmitz 1},
ddc = {610},
cid = {I:(DE-2719)1810004},
pnm = {351 - Brain Function (POF4-351)},
pid = {G:(DE-HGF)POF4-351},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:34289029},
pmc = {pmc:PMC8634576},
doi = {10.1093/cercor/bhab195},
url = {https://pub.dzne.de/record/163463},
}