TY  - JOUR
AU  - Domenighetti, Cloé
AU  - Sugier, Pierre-Emmanuel
AU  - Sreelatha, Ashwin Ashok Kumar
AU  - Schulte, Claudia
AU  - Grover, Sandeep
AU  - Mohamed, Océane
AU  - Portugal, Berta
AU  - May, Patrick
AU  - Bobbili, Dheeraj R
AU  - Radivojkov-Blagojevic, Milena
AU  - Lichtner, Peter
AU  - Singleton, Andrew B
AU  - Hernandez, Dena Michelle Godwin
AU  - Edsall, Connor
AU  - Mellick, George D
AU  - Zimprich, Alexander
AU  - Pirker, Walter
AU  - Rogaeva, Ekaterina
AU  - Lang, Anthony E
AU  - Koks, Sulev
AU  - Taba, Pille
AU  - Lesage, Suzanne
AU  - Brice, Alexis
AU  - Corvol, Jean-Christophe
AU  - Chartier-Harlin, Marie-Christine
AU  - Mutez, Eugénie
AU  - Brockmann, Kathrin
AU  - Deutschländer, Angela B
AU  - Hadjigeorgiou, Georges M
AU  - Dardiotis, Efthimos
AU  - Stefanis, Leonidas
AU  - Simitsi, Athina Maria
AU  - Valente, Enza Maria
AU  - Petrucci, Simona
AU  - Duga, Stefano
AU  - Straniero, Letizia
AU  - Zecchinelli, Anna
AU  - Pezzoli, Gianni
AU  - Brighina, Laura
AU  - Ferrarese, Carlo
AU  - Annesi, Grazia
AU  - Quattrone, Andrea
AU  - Gagliardi, Monica
AU  - Matsuo, Hirotaka
AU  - Kawamura, Yusuke
AU  - Hattori, Nobutaka
AU  - Nishioka, Kenya
AU  - Chung, Sun Ju
AU  - Kim, Yun Joong
AU  - Kolber, Pierre
AU  - van de Warrenburg, Bart Pc
AU  - Bloem, Bastiaan R
AU  - Aasly, Jan
AU  - Toft, Mathias
AU  - Pihlstrøm, Lasse
AU  - Guedes, Leonor Correia
AU  - Ferreira, Joaquim J
AU  - Bardien, Soraya
AU  - Carr, Jonathan
AU  - Tolosa, Eduardo
AU  - Ezquerra, Mario
AU  - Pastor, Pau
AU  - Diez-Fairen, Monica
AU  - Wirdefeldt, Karin
AU  - Pedersen, Nancy L
AU  - Ran, Caroline
AU  - Belin, Andrea C
AU  - Puschmann, Andreas
AU  - Hellberg, Clara
AU  - Clarke, Carl E
AU  - Morrison, Karen E
AU  - Tan, Manuela
AU  - Krainc, Dimitri
AU  - Burbulla, Lena F.
AU  - Farrer, Matt J
AU  - Krüger, Rejko
AU  - Gasser, Thomas
AU  - Sharma, Manu
AU  - Elbaz, Alexis
AU  - Genetics, Comprehensive Unbiaised Risk Factor Assessment for
TI  - Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease.
JO  - Journal of Parkinson's Disease
VL  - 12
IS  - 1
SN  - 1877-718X
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2022-00237
SP  - 267 - 282
PY  - 2022
AB  - Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility that these associations may be explained by reverse causation.To examine associations of lifestyle behaviors with PD using two-sample Mendelian randomisation (MR) and the potential for survival and incidence-prevalence biases.We used summary statistics from publicly available studies to estimate the association of genetic polymorphisms with lifestyle behaviors, and from Courage-PD (7,369 cases, 7,018 controls; European ancestry) to estimate the association of these variants with PD. We used the inverse-variance weighted method to compute odds ratios (ORIVW) of PD and 95
KW  - Aged
KW  - Alcohol Drinking: epidemiology
KW  - Alcohol Drinking: genetics
KW  - Coffee
KW  - Genome-Wide Association Study
KW  - Humans
KW  - Mendelian Randomization Analysis
KW  - Parkinson Disease: etiology
KW  - Parkinson Disease: genetics
KW  - Risk Factors
KW  - Smoking: epidemiology
KW  - Mendelian randomisation (Other)
KW  - Parkinson’s disease (Other)
KW  - Smoking (Other)
KW  - alcohol (Other)
KW  - coffee (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC9211765
C6  - pmid:34633332
DO  - DOI:10.3233/JPD-212851
UR  - https://pub.dzne.de/record/163477
ER  -