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000163481 1001_ $$0P:(DE-2719)9001453$$aLitmeier, Simon$$b0$$eFirst author
000163481 245__ $$aCoronary angiography in acute ischemic stroke patients: frequency and determinants of pathological findings in a multicenter cohort study.
000163481 260__ $$aBerlin$$bSpringer$$c2022
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000163481 520__ $$aMyocardial injury as indicated by cardiac troponin elevation is associated with poor prognosis in acute stroke patients. Coronary angiography (CAG) is the diagnostic gold-standard to rule-out underlying obstructive coronary artery disease (CAD) in these patients. However, weighing risks and benefits of coronary angiography (CAG) against each other is particularly challenging, because stroke patients undergoing CAG may have a higher risk for secondary intracranial bleeding. Current guidelines remain vague. Thus, the aim of this study was to analyze frequency of pathological findings of CAG and associated clinical factors.We analyzed indications and frequency of CAG performed in acute ischemic stroke patients in clinical routine in two European tertiary care hospitals from 2011 to 2018. All data were obtained retrospectively. Multiple logistic regression analyses were performed to identify variables associated with absence of obstructive coronary artery disease defined as presence of at least one coronary vessel stenosis ≥ 50%.A total of 139 AIS patients underwent CAG. Frequent indications for CAG were suspected acute coronary syndrome (N = 114) or scheduled cardiac surgery (N = 25). Acute coronary stenting was applied in 51/139 patients. Among patients with suspected acute coronary syndrome, no obstructive CAD was found in 27/114 patients. Absence of obstructive CAD was associated with insular cortex lesions, no clinical symptoms for ACS, less than three cardiovascular risk factors, younger age and normal wall motion.Several variables suggest absence of CAD in AIS patients and may help in clinical decision making in stroke patients with myocardial injury.
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000163481 650_7 $$2Other$$aAcute ischemic stroke
000163481 650_7 $$2Other$$aHeart and brain axis
000163481 650_7 $$2Other$$aMyocardial injury
000163481 650_7 $$2Other$$aStroke-heart-syndrome
000163481 650_2 $$2MeSH$$aAcute Coronary Syndrome: complications
000163481 650_2 $$2MeSH$$aAcute Coronary Syndrome: diagnosis
000163481 650_2 $$2MeSH$$aCoronary Angiography
000163481 650_2 $$2MeSH$$aCoronary Artery Disease: complications
000163481 650_2 $$2MeSH$$aCoronary Artery Disease: diagnosis
000163481 650_2 $$2MeSH$$aHumans
000163481 650_2 $$2MeSH$$aIschemic Stroke
000163481 650_2 $$2MeSH$$aRetrospective Studies
000163481 650_2 $$2MeSH$$aRisk Factors
000163481 650_2 $$2MeSH$$aStroke: complications
000163481 650_2 $$2MeSH$$aStroke: diagnostic imaging
000163481 650_2 $$2MeSH$$aStroke: epidemiology
000163481 7001_ $$aMeinel, Thomas R$$b1
000163481 7001_ $$0P:(DE-2719)9001452$$avon Rennenberg, Regina$$b2$$udzne
000163481 7001_ $$aKniepert, Joachim U$$b3
000163481 7001_ $$aAudebert, Heinrich J$$b4
000163481 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b5
000163481 7001_ $$aJung, Simon$$b6
000163481 7001_ $$0P:(DE-2719)9001514$$aScheitz, Jan F.$$b7
000163481 7001_ $$0P:(DE-2719)9000234$$aNolte, Christian$$b8
000163481 77318 $$2Crossref$$3journal-article$$a10.1007/s00415-022-11001-5$$bSpringer Science and Business Media LLC$$d2022-02-19$$n7$$p3745-3751$$tJournal of Neurology$$v269$$x0340-5354$$y2022
000163481 773__ $$0PERI:(DE-600)1421299-7$$a10.1007/s00415-022-11001-5$$n7$$p3745-3751$$tJournal of neurology$$v269$$x0340-5354$$y2022
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